Benazepril
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Benazepril 속성
- 녹는점
- 148-149°
- 알파
- D -159° (c = 1.2 in ethanol)
- 끓는 점
- 691.2±55.0 °C(Predicted)
- 밀도
- 1.26±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO에 용해됨
- 산도 계수 (pKa)
- 3.73±0.10(Predicted)
- BCS Class
- 1
- CAS 데이터베이스
- 86541-75-5(CAS DataBase Reference)
안전
| 안전지침서 | 22-24/25 | ||
|---|---|---|---|
| 유해 물질 데이터 | 86541-75-5(Hazardous Substances Data) |
Benazepril MSDS
(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid
Benazepril C화학적 특성, 용도, 생산
정의
ChEBI: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzy e inhibitor benazeprilat in the treatment of hypertension and heart failure.효소 저해제
This ACE-directed pro-drug (FWfree-acid = 424.50 g/mol; CAS 86541-75-5), also known as 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5- tetrahydro-2-oxo-(S-(R*,R*))-1H-1-benzazepine-1-acetic acid, Lotensin and CGS 14824A, is rapidly metabolized to its diacid benazeprilat (CGS 14831; FWfree-diacid = 396.44 g/mol), the latter a potent, long-acting inhibitor of peptidyl-dipeptidase A, or angiotensin I-converting enzyme, IC50 = 1.7 nM. Lotensin is used to treat hypertension, congestive heart failure, and chronic renal failure. The antihypertensive effects of benazepril begin as early as 30 min after a single dose, and those effects during consecutive dosing are also sustained for 24 h with a lesser diurnal variation in blood pressureBenazepril 준비 용품 및 원자재
원자재
N-메틸모폴린
Cinchonidine
아황산
4-나이트로벤젠설포닐 염화물
Tert-butyl ester
Benzyl 2-bromoacetate
소디움 아지이드
Ethyl 2-oxo-4-phenylbutyrate
나트륨 사이아노브로민하이드라이드(나트륨 시아노브롬하이드리드)
준비 용품
Benazepril 공급 업체
글로벌( 149)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 |
wuzhouding@huihecrop.com | China | 886 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| Shandong Hengshannuode Pharmaceutical Technology Co., Ltd. | +8615065888978 |
admin@hsnordpharma.com | China | 92 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9358 | 58 |
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 |
erin@hbldbiotech.com | China | 878 | 58 |