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β-피콜린

β-피콜린
β-피콜린 구조식 이미지
카스 번호:
108-99-6
한글명:
β-피콜린
동의어(한글):
3-메틸피리딘;β-피콜린
상품명:
3-Picoline
동의어(영문):
BETAP;bPicolin;NSC 18251;B-Picoline;m-Picoline;3-PICOLINE;BETA-PICOLINE;Picoline (Beta);3-Methylpyidine;3-Picoline ,99%
CBNumber:
CB5355956
분자식:
C6H7N
포뮬러 무게:
93.13
MOL 파일:
108-99-6.mol

β-피콜린 속성

녹는점
−19 °C(lit.)
끓는 점
144 °C(lit.)
밀도
0.957 g/mL at 25 °C(lit.)
증기 밀도
3.2 (vs air)
증기압
4.4 mm Hg ( 20 °C)
굴절률
n20/D 1.504(lit.)
인화점
97 °F
저장 조건
Flammables area
용해도
alcohol: miscible(lit.)
물리적 상태
Liquid
산도 계수 (pKa)
5.68(at 20℃)
색상
Clear yellow
수소이온지수(pH)
10 (100g/l, H2O, 20℃)
폭발한계
1.3-8.7%(V)
수용성
soluble
Merck
14,7401
BRN
1366
안정성
Stable. Flammable. Hygroscopic. Incompatible with oxidizing agents.
InChIKey
ITQTTZVARXURQS-UHFFFAOYSA-N
CAS 데이터베이스
108-99-6(CAS DataBase Reference)
NIST
Pyridine, 3-methyl-(108-99-6)
EPA
Pyridine, 3-methyl-(108-99-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 C,Xn
위험 카페고리 넘버 10-20/21/22-34-36/37/38-22
안전지침서 16-26-36/37/39-45-36
유엔번호(UN No.) UN 2313 3/PG 3
WGK 독일 1
RTECS 번호 TJ5000000
자연 발화 온도 ~1000 °F
TSCA Yes
위험 등급 3
포장분류 III
HS 번호 29333999
유해 물질 데이터 108-99-6(Hazardous Substances Data)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H226 인화성 액체 및 증기 인화성 액체 구분 3 경고
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H372 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴 특정 표적장기 독성 - 반복 노출 구분 1 위험 P260, P264, P270, P314, P501
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P233 용기를 단단히 밀폐하시오. 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 보관하시오.
P240 용기와 수용설비를 접지 및 접합시키시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P310 즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P307+P311 노출된 경우,독성 물질 센터 또는 의사에게 전화하기
P405 밀봉하여 저장하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

β-피콜린 MSDS


3-Methylpyridine

β-피콜린 C화학적 특성, 용도, 생산

화학적 성질

colourless liquid

화학적 성질

Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.

출처

3-Methylpyridine is released during the production of fossil fuels. It is formed as a byproduct of coke production (Naizer and Mashek 1974); is present in coal gasification wastewater (Giabbai et al 1985); is a contaminant of groundwater near underground coal gasification sites (Stuermer and Morris 1982); is a component of groundwater contaminated with coal-tar waste (Pereira et al 1983); and is found in shale oil wastewaters (Hawthorne and Sievers 1984; Hawthorne et al 1985). It is formed upon pyrolysis of wood (Yasuhara and Sugiura 1987) and is a constituent of cigarette (IARC 1986; Sakuma et al 1984) and marijuana (Merli et al 1981) smoke. 3-Methylpyridine is formed during the thermal degradation of nicotine in the burning of tobacco (Schmelz et al 1979). The chemical is also present in brewed coffee (Sasaki et al 1987) and black tea (Werkoff and Hubert 1975). 3-Methylpyridine has been detected along with other micropollutants in the Barcelona water supply (Rivera et al 1987). Methods for the biological treatment of wastewater high in the chemical have been developed (Roubiskova 1986). The biodegradability of 3-methylpyridine has been studied in various soils (Sims and Sommers 1985, 1986).

용도

A useful precursor to agrochemicals and antidotes for organophosphate poisoning.

용도

Solvent; intermediate in the dye and resins industries; in the manufacture of insecticides, waterproofing agents, niacin, and niacinamide.

생산 방법

There are three major methods of 3-methylpyridine manufacturing: (1) vaporphase reaction of acetaldehyde and ammonia with formaldehyde and/or methanol in the presence of an acidic catalyst (e.g. Si02A103); (2) extraction from bone oil; (3) dry distillation of bones or coal (Hawley 1977; Parmeggiani 1983).

일반 설명

Colorless liquid with a sweetish odor .

공기와 물의 반응

Highly Flammable. Water soluble.

반응 프로필

3-Picoline may react with oxidizing materials . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

건강위험

HARMFUL if swallowed, inhaled or absorbed through skin. Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes and skin. Inhalation may be fatal as a result of spasm, inflammation of larynx and bronchi, chemical pneumonitis and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.

건강위험

Clinical signs of intoxication caused by alkyl derivatives of pyridine including weight loss, diarrhea, weakness, ataxia and unconsciousness (RTECS 1988). Poisoning in a 32 year old male exposed to industrial vapors was characterized by unique autonomic disturbances against asthenic background (angiodystonia, tendency toward hypotonia and bradycardia, increase of pilomotor reflex, and disturbances of thermoregulation) and by polyneuritic phenomena (Budanova 1973).
A 58-year old man occupationally exposed to 3-methylpyridine for 11 years showed an increase in liver glutamic pyruvic transaminase and glutamic oxaloacetic transaminase (Caballeria et al 1979).

화재위험

Special Hazards of Combustion Products: Vapors may travel considerable distance to a source of ignition and flashback. Forms explosive mixtures in air. Emits toxic fumes under fire conditions.

공업 용도

3-Methylpyridine can be used as a solvent, an intermediate in the dye and resin industries, in the manufacture of insecticides, as a waterproofing agent, in synthesis of pharmaceuticals, as rubber accelerators and a laboratory reagent (Hawley 1977; Windholz et al 1983). It is also used as a chemical intermediate for niacin and niacinamide (anti-pellagra vitamins) production. U.S. production in 1978 was estimated at 1.32-2.07xl07 kg (HSDB 1988).

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx.

잠재적 노출

(o-isomer); Suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (m-isomer): Possible risk of forming tumors, Primary irritant (w/o allergic reaction). Picolines are used as intermediates in pharmaceutical manufacture, pesticide manufacture; and in the manufacture of dyes and rubber chemicals. It is also used as a solvent.

신진 대사

Methylpyridines can be absorbed by inhalation, ingestion and skin contact (Parmeggiana 1983). The percentage uptake of 3-methylpyridine by rats increased with dosage; elimination occurred in 2 phases, the duration of which also was dose dependent (Zharikov and Titov 1982). Addition of a methyl group to pyridine greatly increased the rate of uptake into liver, kidney and brain of rats (Zharikov et al 1983). The position of the methyl group drastically influenced the pharmacokinetics of the methylpyridines, with 3-methylpyridine exhibiting the longest biological halflife.
N-Oxidation is a minor route for 3-methylpyridine biotransformation with 6.6, 4.2, and 0.7% biotransformation of the dose, respectively, being excreted in the urine of mice, rats and guinea pigs receiving i.p. doses of the chemical (Gorrod and Damani 1980). Urinary excretion of 3-methylpyridine N-oxide was increased following pretreatment of mice with phenobarbital but 3-methylcholanthrene had no appreciable effect on N-oxide elimination (Gorrod and Damani 1979a, 1979b). The structure of 3-methylpyridine N-oxide has been verified by mass spectrometry (Cowan et al 1978).

운송 방법

UN2313 Picolines, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

In general, the same methods of purification that are described for 2-methylpyridine can be used. However, 3-methylpyridine often contains 4-methylpyridine and 2,6-lutidine, neither of which can be removed satisfactorily by drying and fractionation, or by using the ZnCl2 complex. Biddiscombe and Handley [J Chem Soc 1957 1954], after steam distillation as for 2-methylpyridine, treated the residue with urea to remove 2,6-lutidine, then azeotropically distilled with acetic acid (the azeotrope had b 114.5o/712mm), and recovered the base by adding excess of aqueous 30% NaOH, drying with solid NaOH and carefully fractionally distilling. The distillate is then fractionally crystallised by slow partial freezing. An alternative treatment [Reithoff et al. Ind Eng Chem (Anal Edn) 18 458 1946] is to reflux the crude base (500mL) for 20-24hours with a mixture of acetic anhydride (125g) and phthalic anhydride (125g) followed by distillation until phthalic anhydride begins to pass over. The distillate is treated with NaOH (250g in 1.5L of water) and then steam distilled. Addition of solid NaOH (250g) to this distillate (ca 2L) led to the separation of 3-methylpyridine which is removed, dried (K2CO3, then BaO) and fractionally distilled. (Subsequent fractional freezing would probably be advantageous.) The hydrochloride has m 85o, and the picrate has m 153o(from Me2CO, EtOH or H2O). [Beilstein 20 III/IV 2710, 20/5 V 506.]

비 호환성

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks copper and its alloys.

β-피콜린 준비 용품 및 원자재

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