아목사핀
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아목사핀 속성
- 녹는점
- 175-1760C
- 끓는 점
- 469.9±55.0 °C(Predicted)
- 밀도
- 1.2613 (rough estimate)
- 굴절률
- 1.5800 (estimate)
- 인화점
- 9℃
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 메탄올 에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- pKa 7.6 (Uncertain)
- 색상
- 벤젠/애완동물 에테르에서 침전된 결정
- Merck
- 14,576
- 안정성
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- CAS 데이터베이스
- 14028-44-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 22 | ||
안전지침서 | 36 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 3 | ||
RTECS 번호 | HQ4025500 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 2934990002 | ||
독성 | LD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972) |
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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아목사핀 C화학적 특성, 용도, 생산
개요
Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM. It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C, respectively), dopamine D2, 3, 4 (Kd = 160 nM for D2), α1-adrenergic (Kd = 50 nM), and histamine H1 (Kd = 25 nM) receptors.화학적 성질
Crystalline Solid용도
Amoxapine is intended more for relieving symptoms in patients with neurotic or situational depression. It has a number of serious side effects.정의
ChEBI: A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.일반 설명
Consideration of the structure of amoxapine, 2-chloro-11-(1-piperazinyl)dibenz-[b,f] [1,4]oxazepine (Asendin), reinforcesthe fact that many antidepressants are very closelyrelated to antipsychotics. Indeed, some, including amoxapine,have significant effects at D2 receptors. The Nmethyl–substituted relative of amoxapine is the antipsychoticloxapine (Loxitane). The 8-hydroxy metabolite ofamoxapine is reportedly active as an antidepressant and asa D2 receptor blocker.Mechanism of action
Additionally, it is the N-desmethyl metabolite of the antipsychotic loxapine. Amoxapine differs structurally from the other secondary TCAs in that it has both a nitrogen and an oxygen atom in its 7-membered central ring and a piperazinyl ring rather than a propylamino side chain attached to the central ring.Amoxapine is a less potent inhibitor of neuronal NE reuptake compared with the other secondary TCAs, with a mechanism of action similar to that of desipramine.Pharmacology
The antidepressant action of amoxapine is comparable to that of imipramine and amitriptyline. It exhibits antagonistic activity on dopamine (D2) receptors.Pharmacokinetics
Amoxapine shares the toxic potentials of the TCAs, and the usual precautions of TCA administration should be observed. Amoxapine resembles the atypical antipsychotic drugs in its intermediate affinity as an antagonist of dopamine-2 and of 5-HT2 receptors. Amoxapine is rapidly and almost completely absorbed from the gastrointestinal (GI) tract. Amoxapine and its 8-hydroxyamoxapine metabolite have been detected in human milk at concentrations below steady-state therapeutic concentrations.Clinical Use
Amoxapine is a dibenzoxazepine TCA with antidepressant and antipsychotic effects that has shown therapeutic effectiveness in patients with delusional depression.Safety Profile
Poison by ingestion andintraperitoneal routes. Human systemic effects byingestion: acute renal failure, acute tubular necrosis, BPlowering, coma, convulsions, decreased body temperature,EKG changes, excitement, fasciculations, heart ratechanges, hype신진 대사
Amoxapine has the shortest elimination time (~8 hours) of the secondary TCAs. It is metabolized in the liver principally to 8-hydroxyamoxapine and to 7-hydroxyamoxapine. Both of these metabolites are pharmacologically active and have half-lives of 30 and 6.5 hours, respectively. The hydroxylation of amoxapine is inhibited by ketoconazole, suggesting the involvement of CYP3A4."아목사핀 준비 용품 및 원자재
원자재
준비 용품
아목사핀 공급 업체
글로벌( 225)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21700 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
아목사핀 관련 검색:
트라조돈 2-클로로다이벤즈[b,f][1,4]옥사제핀-11(10H)-원 아목사핀 다이에틸 아미노말로네이트 하이드로클로라이드
Loxapine succinate salt
loxapine
Amoxapine-d8
7-Hydroxy Amoxapine-d8
8-METHOXY LOXAPINE
8-hydroxyloxapine
7-hydroxyloxapine
8-HYDROXY AMOXAPINE
8-Hydroxy Amoxapine-d8
11-Piperazinyldibenz[b,f][1,4]oxazepine
2-(4-CHLOROPHENOXY)ANILINE
10,11-DIHYDRODIBENZ[B,F][1,4]OXAZEPIN-11-ONE
Amoxapine Impurity 7
Benzenamine, 4-chloro-2-(iminophenylmethyl)-