2-Chloroadenosine
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2-Chloroadenosine 속성
- 녹는점
- 162 °C
- 끓는 점
- 591.8±60.0 °C(Predicted)
- 밀도
- 1.8359 (rough estimate)
- 굴절률
- -50 ° (C=0.1, H2O)
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- H2O: 10 mg/mL, 투명, 무색
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 13.05±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 물에 용해됩니다.
- BRN
- 43957
- InChIKey
- BIXYYZIIJIXVFW-UUOKFMHZSA-N
- CAS 데이터베이스
- 146-77-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 24/25 | ||
---|---|---|---|
WGK 독일 | 3 | ||
RTECS 번호 | AU7357550 | ||
HS 번호 | 29349990 | ||
독성 | LD50 oral in mouse: > 100mg/kg |
2-Chloroadenosine C화학적 특성, 용도, 생산
화학적 성질
White to Off-White Crystalline Sold용도
Selective A1 adenosine receptor agonist. Since 2-chloroadenosine is not deaminated by adenosine deaminase and is less rapidly taken up by the brain than adenosine, 2-chloroadenosine led to more marked increase in CBF than adenosine.정의
A metabolically stable analog of adenosine which acts as an adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system.생물학적 활성
Metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (K i values are 300, 80 and 1900 nM for A 1 , A 2A and A 3 receptors respectively). Anticonvulsive in vivo .Pharmacology
2-chloroadenosine (2-CAdo) is an adenosine deaminase-resistant analogue of adenosine, widely used as an adenosine receptor agonist. This compound has been shown to induce apoptosis in several cell types either via activation of adenosine receptors or via intracellular metabolism. However, the molecular mechanisms of 2-CAdo-induced apoptosis are unclear. Here, we analyzed the effects of 2-CAdo in the leukemia cell line EHEB. 2-CAdo was found to induce apoptosis in EHEB cells, as shown by caspase-3 activation, DNA fragmentation, poly(ADP-ribose) polymerase (PARP) cleavage and phosphatidylserine exposure. Cytotoxicity of 2-CAdo was completely suppressed by 5-iodotubercidin, an adenosine kinase inhibitor, indicating that apoptosis induced by 2-CAdo was the result of its intracellular metabolism. Accordingly, we found that 2-CAdo was efficiently converted into 2-chloroATP. In parallel, a decrease of intracellular ATP concentration as well as a general inhibition of macromolecular synthesis, involving DNA, RNA and protein synthesis, was observed. Moreover, 2-CAdo induced cytochrome c release into the cytosol, indicating activation of the intrinsic pathway of apoptosis. This was found associated with a decline in Mcl-1 protein level and p53-independent. Inhibition of AMP deaminase by coformycin markedly prevented ATP depletion, and also significantly reduced 2-CAdo cytotoxicity and caspase-3 activation. In conclusion, our data show that intracellular metabolism of 2-CAdo can lead to activation of the intrinsic pathway of apoptosis and that ATP depletion, in addition to the accumulation of the triphosphate analogue, contributes to 2-CAdo-induced apoptosis.Purification Methods
Purify 2-chloroadenosine by recrystallisation from H2O (~1% in cold), and it has max at 264 nm (pH 1 and 7) and 265 nm (pH 13) in H2O. [Brown & Weliky J Org Chem 23 125 1958, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, IR: Davoll & Lewy J Am Chem Soc 74 1563 1952, Beilstein 26 III/IV 3725.]2-Chloroadenosine 준비 용품 및 원자재
원자재
준비 용품
2-Chloroadenosine 공급 업체
글로벌( 464)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1320 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 |
sales@zhswyy.com | China | 338 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15371 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9352 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
2-Chloroadenosine 관련 검색:
아데닌 퓨린 클라드리빈
6-AMINO-2-CHLOROPURINE RIBOSIDE HEMIHYDRATE,2-CHLOROADENOSINE HEMIDYDRATE,2-CHLOROADENOSINE HEMIHYDRATE
2-Chloroadenosine
2-Amino-6-chloropurine-9-riboside
6-Deamino-6-chloroadenosine
8-Chloroadenosine
2-Chloropurine
2-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT,2-chloroadenosine-3’,5’-cyclicmonophosphate,sodiumsalt(2-cl-camp
2-CHLORO-9-(2,3-O-ISOPROPYLIDENE-BETA-D-RIBOFURANOSYL)ADENINE
(+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine
N-Cyclopentyl-2-chloroadenosine
2-CHLORO-9-(2-3-O-ISOPROPYLIDENE-BETA-D-RIBOFURANOSYLURONIC ACID)ADENINE
5'-sulfamoyl-2-chloroadenosine
2'-MECCPA
2-CHLOROADENOSINE, [8-3H]-
2-CHLOROADENOSINE, [8-14C]-