BERBAMINE

BERBAMINE C화학적 특성, 용도, 생산

개요

Berbamine is an alkaloid, separated from Berberidaceae, Menispermaceae, or Ranunculaceae plants. Most of Berberidaceae plants have medicinal value, including their root, root bark, and stem. The plants of Berberis L. and Mahonia Nutt. contain many alkaloids, the most important of which are berberine and a small amount of palmatine, jatrorrhizine, berbamine, oxyacanthine, and so on. These compounds have many biological activities and have been used to replace goldthread and golden cypress. Also they are well succedaneums of berberine in Chinese and Western medicine. Traditional Chinese medicine Oregon grape root has different therapeutic effects for dysentery, enteritis, children pneumonia, and chronic bronchitis. The major treatment diseases of Chinese mahonia are bacillary dysentery, acute gastritis, infectious hepatitis, pneumonia, tuberculosis, bronchitis, sore throat, and so on.

물리적 성질

Appearance: odorless and bitter white crystalline, powder, belongs to bisbenzylisoquinoline alkaloid. Melting point: 197–210?°C in petroleum ether. Solubility: easily soluble in dilute hydrochloric acid, sulfuric acid, ethanol, chloroform, and acetone; soluble in ether; slightly soluble in boiling water and petroleum ether; but insoluble in cold water, ammonia, sodium carbonate, and calcium hydroxide solution.

역사

Berbamine is an alkaloid mainly from Berberis julianae, Berberis wilsonae, Berberis poiretii, and huanglumu, which belong to Berberidaceae berberis and Mahonia. Nowadays, it mainly comes from chemical synthesis. Berbamine hydrochloride is contained in the 13th volume of the book, Hua xue yao ping di biao sheng guo biao. As early as 1940, the United States scholars had obtained berbamine from Mahonia . Chinese scholars began the research of berbamine extraction and pharmacological activities since the 1980s in the last century .
Although the berbamine study in our country later than the west, the traditional Chinese medicine Berberi’s medicinal records can be traced back to the Tang Dynasty. The book Tang Ben Cao recorded that Oregon grape root could be a therapy for aphtha, kill insects, and remove hot gas in the body. In the Ming Dynasty the book Ben Cao Gang Mu recorded that Oregon grape root could treat metrorrhagia. Now, berbamine is widely used for leukopenia.

용도

antihypertensive, skeletal muscle relaxant

Indications

Berbamine is contained in the 13th volume of the book, National Standards for Chemical Drugs.
The current clinical dosage is berbamine hydrochloride tablets. It is used in the prevention and treatment of patients with cancer, which is due to radiotherapy- and chemotherapy-induced neutropenia or due to benzene poisoning, radioactive substances, and drug-induced neutropenia.

Pharmacology

Berbamine can promote hematopoietic function, stimulate myeloid proliferation.
Also berbamine can enhance the content of hematopoietic stem cell and granulocyte-colony stimulating factor (G-CSF), then increase the proliferation and differentiation of bone marrow hematopoietic stem cells and granule progenitor cell, which increase the number of peripheral blood leukocytes. Preclinical and clinical studies showed that berbamine was good for the treatment of leukopenia induced by chemotherapy. Berbamine can inhibit the proliferation of many kinds of tumor cells, such as the human high metastatic breast cancer cells MDA-MB-231, non-small cell lung cancer cells A549, liver cancer cells SMMC772l and HepG2, multiple myeloma cells KM3 and RPMl8226, chronic myeloid leukemia (CML) cells KU812, and imatinib-resistant K562 cells .

Clinical Use

Berbamine is used for the prevention and treatment of cancer patients with neutropenia due to radiotherapy, chemotherapy , benzene poisoning, radioactive substances, and drug.

효소 저해제

This antihypertensive alkaloid (FW = 608.72 g/mol; CAS 478-61-5; Symbol: BBM) from Berberis lyceum and Mahonia swaseyi is a dihydropyridineclass calcium ion blocker. Berbamine also inhibits KM3 cell growth by inducing G1 arrest as well as apoptosis, by blocking NF-kB signaling through up-regulation of A20, down-regulation of IKKa, p-IkBa, and then inhibition of p65 nuclear translocation, all with a resultant decrease in the expression of the downstream targets of NF- kB. BBM potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting Ca2+/calmodulin-dependent protein kinase II (CAMKII). BBM likewise inhibits in vivo tumorigenicity of liver cancer cells in NOD/SCID mice. These effects are recapitulated by short hairpin RNA-mediated CAMKII knockdown, whereas CAMKII overexpression promotes cancer cell proliferation and increases the resistance of liver cancer cells to BBM. CAMKII was hyperphosphorylated in liver tumors compared with the paired peri-tumor tissues, supporting a role of CAMKII in promoting human liver cancer progression and the clinical potential of BBM in liver cancer therapies.

Purification Methods

Crystallise berbamine from pet ether or *C6H6 (with 1*C6H6 m 129-134o). [Bick Aust J Chem 9 111, 118 1956, Beilstein 27 II 891, 27 III/IV 8732.]

BERBAMINE 준비 용품 및 원자재

원자재

준비 용품

BERBAMINE 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	chem1022@hengdian-group.com	China	1469	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58

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