3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE
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3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE 속성
- 녹는점
- 220°C dec.
- 끓는 점
- 493.6±28.0 °C(Predicted)
- 밀도
- 1.68±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO: 용해성10mg/mL, 투명
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 1.51±0.30(Predicted)
- 색상
- 주황색에서 진한 주황색-빨간색까지
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE C화학적 특성, 용도, 생산
개요
Tirapazamine is a hypoxia-activated anticancer agent. It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity. Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively). It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions. In vivo, tirapazamine sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model. Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.화학적 성질
Orange Needles용도
A bioreductive anticancer agent. Selectively toxic to cells under hypoxic conditions. An antineoplastic정의
ChEBI: A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE 준비 용품 및 원자재
원자재
1,2,4-Benzotriazine,3-chloro-, 1-oxide
1,2,4-benzotriazin-3-amine
2-BROMO-3-AMINOANISOLE
디니트로 벤젠
벤조퓨라잔 1-옥사이드
2-니트로아닐린
시안아미드
O-플루오로니트로벤젠
준비 용품
3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE 공급 업체
글로벌( 146)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 |
ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 |
info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
| CR Corporation Lomited | |
fred.wen@crcorporation.cn | CHINA | 12069 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |