ChemicalBook
Chinese English Japanese Germany Korea

라니티딘

라니티딘
라니티딘 구조식 이미지
카스 번호:
66357-35-5
한글명:
라니티딘
동의어(한글):
라니티딘
상품명:
Ranitidine hydrochloride
동의어(영문):
U1cex;Taural;Zantae;Zantic;Sostril;Trigger;Terposen;U1tidine;Ranitidin;RANITIDINE
CBNumber:
CB5480252
분자식:
C13H22N4O3S
포뮬러 무게:
314.4
MOL 파일:
66357-35-5.mol

라니티딘 속성

녹는점
69-70°C
저장 조건
Desiccate at +4°C
용해도
H2O: 1.8 mg/mL
산도 계수 (pKa)
pKa 2.19±0.04 (Uncertain)
물리적 상태
solid
색상
tan
수용성
24.7 mg/mL
CAS 데이터베이스
66357-35-5(CAS DataBase Reference)
NIST
Ranitidine(66357-35-5)

안전

안전지침서 22-24/25
WGK 독일 2
RTECS 번호 KM6557000
유해 물질 데이터 66357-35-5(Hazardous Substances Data)

라니티딘 MSDS


Ranitidine hydrochloride

라니티딘 C화학적 특성, 용도, 생산

용도

Antagonist (to histamine H2receptors).

상표명

Zantac (GlaxoSmithKline).

일반 설명

Ranitidine, N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thiol] ethyl]-N'-methyl-2-nitro-l,1-ethenediamine (Zantac), is a white solid, which inits hydrochloride salt form is highly soluble in water. It is anaminoalkyl furan derivative with pKa values of 2.7 (sidechain) and 8.2 (dimethylamino). Ranitidine is more potentthan cimetidine, but less potent than famotidine. Likeother H2-antagonists, it does not appear to bind to otherreceptors.
Bioavailability of an oral dose of ranitidine is about 50%and is not significantly affected by the presence of food.Some antacids may reduce ranitidine absorption and shouldnot be taken within 1 hour of administration of this drug. Theplasma half-life of the drug is 2 to 3 hours, and it is excretedalong with its metabolites in the urine. Three metabolites, ranitidineN-oxide, ranitidine S-oxide, and desmethyl ranitidine,have been identified. Ranitidine is only a weak inhibitor ofthe hepatic cytochrome isozymes, and recommended doses ofthe drug do not appear to inhibit the metabolism of otherdrugs. However, there have been isolated reports of drug interactions(warfarin, triazolam) that suggest that ranitidinemay affect the bioavailability of certain drugs by someunidentified mechanism, perhaps by pH-dependent effect onabsorption or a change in volume of distribution.
In addition to being available in various dosage forms asthe hydrochloride salt, ranitidine is also available as a bismuthcitrate salt for use with the macrolide antibiotic clarithromycinin treating patients with an active duodenalulcer associated with H. pylori infection. Eradication of H.pylori reduces the risk of duodenal ulcer recurrence.

생물학적 활성

Potent, selective and competitive histamine H 2 receptor antagonist (pA 2 = 6.95-7.2). In vivo, inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food. Also inhibits aspirin-induced gastric lesions.

색상 색인 번호

Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.

라니티딘 준비 용품 및 원자재

원자재

준비 용품


라니티딘 공급 업체

글로벌( 127)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21922 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15884 69
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 sales@RHFChem.com China 2349 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9922 62
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 13922 59

Copyright 2019 © ChemicalBook. All rights reserved