ChemicalBook
Chinese English Japanese Germany Korea

아세토페논

아세토페논
아세토페논 구조식 이미지
카스 번호:
98-86-2
한글명:
아세토페논
동의어(한글):
아세토페논;아세토펜온;아세토페논;1-페닐에탄온;아세틸벤젠;벤조일메티드;페닐메틸케톤;히프논;하이프논;1-페닐-1-에탄온;메틸 페닐 케톤;에탄온, 1-페닐-;페닐 메틸 케톤
상품명:
Acetophenone
동의어(영문):
Dymex;HYPNONE;FEMA 2009;Acetofenon;Acetophene;hypnon[qr];phenacycle;usafek-496;Acetophenon;ACETPHENONE
CBNumber:
CB5694882
분자식:
C8H8O
포뮬러 무게:
120.15
MOL 파일:
98-86-2.mol

아세토페논 속성

녹는점
19-20 °C (lit.)
끓는 점
202 °C (lit.)
밀도
1.03 g/mL at 25 °C (lit.)
증기 밀도
4.1 (vs air)
증기압
0.45 mm Hg ( 25 °C)
굴절률
n20/D 1.534(lit.)
FEMA
2009 | ACETOPHENONE
인화점
180 °F
저장 조건
Store below +30°C.
용해도
6.1g/l
물리적 상태
Liquid
색상
Clear colorless to light yellow
상대극성
4.4
냄새
Pungent, floral odor
폭발한계
1.4-5.2%(V)
수용성
5.5 g/L (20 ºC)
Merck
14,73
JECFA Number
806
BRN
605842
노출 한도
No exposure limits are set. The health hazard from exposure to this compound should be low, due to its low vapor pressure and low toxicity.
안정성
Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Combustible.
InChIKey
KWOLFJPFCHCOCG-UHFFFAOYSA-N
CAS 데이터베이스
98-86-2(CAS DataBase Reference)
NIST
Acetophenone(98-86-2)
EPA
Acetophenone (98-86-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T,F
위험 카페고리 넘버 22-36-63-43-36/37/38-23/24/25-45-39/23/24/25-11-67-40
안전지침서 26-36/37-24/25-23-53-45-16-7
유엔번호(UN No.) UN 1593 6.1/PG 3
WGK 독일 1
RTECS 번호 AM5250000
F 고인화성물질 8
자연 발화 온도 570 °C
TSCA Yes
포장분류 III
HS 번호 29143900
유해 물질 데이터 98-86-2(Hazardous Substances Data)
독성 LD50 orally in rats: 0.90 g/kg (Smyth, Carpenter)
기존화학 물질 KE-28355
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H311 피부와 접촉하면 유독함 급성 독성 물질 - 경피 구분 3 위험 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H331 흡입하면 유독함 급성 독성 물질 흡입 구분 3 위험 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H336 졸음 또는 현기증을 일으킬 수 있음 특정표적장기 독성 물질(1회 노출);마취작용 구분 3 경고 P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오
P311 의료기관(의사)의 진찰을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P405 밀봉하여 저장하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
2
2 0

아세토페논 MSDS


1-Phenylethanone

아세토페논 C화학적 특성, 용도, 생산

물성

물에는 거의 녹지 않으나, 에탄올·에테르·클로로폼 등의 유기용매에는 잘 녹는다.

용도

산화를 방지하며 트고 거칠어진 피부를 개선하는데 도움을 주며 피부에 보습기능을 향상시켜주고 자극 받은 피부를 진정, 보호해 피부장벽을 강화 시켜주는데 도움을 줍니다.

용도

예전에는 힙논이라는 이름의 최면제로서 사용되었으나, 현재는 향료와 수지 등을 제조할 때에 쓰이는 원료이다.

개요

Acetophenone is the simplest aromatic ketone and is a clear liquid/crystal and very slightly soluble in water with a sweet pungent taste and odour resembling oranges. It is used as a polymerisation catalyst for the manufacture of olefins. Acetophenone is used in perfumery as a fragrance ingredient in soaps, detergents, creams, lotions, and perfumes; as a flavouring agent in foods, non-alcoholic beverages, and tobacco; as a specialty solvent for plastics and resins; as a catalyst for the polymerisation of olefins; and as a photosensitiser in organic syntheses. Acetophenone is a raw material for the synthesis of some pharmaceuticals and is also listed as an approved excipient by the U.S. FDA. Acetophenone occurs naturally in many foods such as apple, apricot, banana, and beef. Acetophenone has been detected in ambient air and drinking water; exposure of the general public may occur through the inhalation of contaminated air or the consumption of contaminated water. It is highly flammable and will get easily ignited by heat, sparks, or flames, and the vapours may form explosive mixtures with air.

화학적 성질

Acetophenone is a colorless, oily liquid with a sweet, floral odor.It is a naturally occurring component of a large number of foods and essential oils.
Acetophenone can be hydrogenated catalytically to 1-phenylethanol. It is obtained as a by-product in the Hock phenol synthesis and is purified from the high-boiling residue by distillation. The quantities obtained from this source satisfy the present demand.
Acetophenone is used for perfuming detergents and industrial products and is an intermediate in the synthesis of other fragrance materials.

화학적 성질

Acetophenone has a characteristic sweet, pungent and strong medicinal odor with a bitter, aromatic cherry branch taste. It is useful in flavors of grape, cherry and tobacco

출처

Reported found in cocoa, beef, raspberry, peas, and concord grape

용도

Solvent for Resins, Plastics, Cellulose Ethers and Esters, Intermediate for the F&F market.

용도

Acetophenone is used in perfumery, as aphotosensitizer in organic synthesis, and asa catalyst in olefin polymerization.In perfumery to impart an orange-blossom-like odor; in organic syntheses, especially. as photosensitizer.

용도

Acetophenone is a reagent used in the production of fragrances and resin polymers.

정의

ChEBI: A methyl ketone that is acetone in which one of the hydrogens of the methyl group has been replaced by a phenyl group.

제조 방법

From benzene and acetylchloride in the presence of aluminum chloride or by catalytic oxidation of ethyl benzene; also prepared by fractional distillation and crystallization from the essential oil of Stirlingia latifolia.

Aroma threshold values

Detection: 170 ppb; Recognition: 2.9 ppm

Taste threshold values

Taste characteristics at 10 ppm: sweet, nutty, benzaldehyde with musty, fruity notes

Synthesis Reference(s)

Canadian Journal of Chemistry, 56, p. 2269, 1978 DOI: 10.1139/v78-373
Chemical and Pharmaceutical Bulletin, 31, p. 4209, 1983 DOI: 10.1248/cpb.31.4209

일반 설명

A colorless liquid with a sweet pungent taste and odor resembling the odor of oranges. Melting point 20.5°C (68.9°F); freezes under cool conditions. Slightly soluble in water and denser than water. Hence sinks in water. Vapor heavier than air. Flash point 180°F. A mild irritant to skin and eyes. Vapors can be narcotic in high concentrations. Used as a flavoring, solvent, and polymerization catalyst.

공기와 물의 반응

Slightly soluble in water.

반응 프로필

Acetophenone reacts with many acids and bases liberating heat and flammable gases (e.g., H2). Reacts with many oxidizing agents. Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. The amount of heat in these reactions may be sufficient to start a fire in the unreacted portion. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.

건강위험

Acetophenone is an irritant, mutagen, and amildly toxic compound. In rabbits 0.77 mgproduced severe eye irritation, but the actionon skin was mild. In mice, subcutaneousadministration of this compound producedsleep; a dose of 330 mg/kg was lethal.
LD50 value, intraperitoneal (mice): 200mg/kg
No symptoms of severe toxicity, nor its carcinogenicityin humans, has been reported..

화재위험

Combustible liquid; flash point (closed cup) 82°C (180°F); vapor pressure 1 torr at 37°C (98.6°F); vapor density 4.1 (air = 1); autoignition temperature 570°C (1058°F); fire-extinguishing agent: dry chemical, foam, or CO2; water may cause frothing, but it can be used to flush and dilute the spill. Its reaction with strong oxidizers may be violent.

Safety Profile

Poison by intraperitoneal and subcutaneous routesModerately toxic by ingestion. A skin and severe eye irritant. Mutation data reported. Narcotic in high concentration. A hypnotic. Flammable liquid. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also IGTONES

잠재적 노출

Acetophenone is used as a solvent and in perfume manufacture to impact a pleasant jasmine or orange-blossom odor. It is used as a catalyst in olefin polymerization and as a flavorant in tobacco. It is also used in the synthesis of pharmaceuticals

Carcinogenicity

No carcinogenicity studies were identified for acetophenone. The U.S. EPA has classified acetophenone as a Category D, not classifiable as to human carcinogenicity.

환경귀착

It is unclear what mechanism is responsible for the central nervous system depression observed following high doses of acetophenone. In vitro evaluations have demonstrated that acetophenone suppresses voltage-gated ion channels in olfactory receptor cells and retinal neurons; however, it is unclear if this is related to any of the observed toxicity in animal studies.

신진 대사

At one time, acetophenone was used as a hypnotic. Its conversion to benzoic acid and methylphenylcarbinol in dogs and rabbits was observed by a number of early workers. Small amounts are also excreted as mandelic acid. In the rabbit about half the dose is excreted as methylphenylcarbinyl glucuronide and about 20 % as hippuric acid. It is probable that the ketone is first asymmetrically reduced to the carbinol, which is the precursor of benzoic and mandelic acids.

운송 방법

UN1993 Flammable liquids, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, Technical Name Required.

Purification Methods

Dry it by fractional distillation or by standing with anhydrous CaSO4 or CaCl2 for several days, followed by fractional distillation under reduced pressure (from P2O5, optional), and careful, slow and repeated partial crystallisations from the liquid at 0o excluding light and moisture. It can also be crystallised at low temperatures from isopentane. Distillation can be followed by purification using gas-liquid chromatography [Earls & Jones J Chem Soc, Faraday Trans 1 71 2186 1975.] [Beilstein 7 H 271, 7 IV 619.] § A commercial polystyrene supported version is available — scavenger resin (for diol substrates).

Toxicity evaluation

The production and use of acetophenone as a specialty solvent and fragrance and flavor additive may result in environmental releases to the air, water, and soil. Acetophenone is slightly soluble in water and freely soluble in alcohol, chloroform, fatty oils, and glycerol. The vapor pressure at 25 °C is 0.4 mmHg, the Henry’s law constant is estimated to be 1.04×105 atmm3 mol-1, and the octanol/water partition coefficient (log Kow) is 1.58.
If released to the soil, acetophenone is expected to have high mobility, with volatilization from moist soils. If released to the water, volatilization is anticipated from the surface and acetophenone is not anticipated to adsorb to sediment. The potential for bioconcentration in aquatic organisms is predicted to be low. If released to the atmosphere, the half-life is anticipated to be 6 days, with degradation occurring by reaction with photochemically produced hydroxyl radicals.

비 호환성

May form explosive mixture with air. See flash point, above. Reacts violently with strong oxidizers, many acids, bases, amines, amides, and inorganic hydroxides; alkali metals; hydrides, and nitrides. Reacts with reducing agents; alkali metals; hydrides, nitrides. Contact with all preceding materials release heat and flammable gases, including hydrogen; the heat may be sufficient enough to result in fire. Incompatible with aldehydes, aliphatic amines, alkanolamines, cyanides, isocyanates, organic acids, peroxides; perchloric acid. May attack plastics, and some rubbers and coatings

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration, preferably with a flammable solvent

아세토페논 준비 용품 및 원자재

원자재

준비 용품


아세토페논 공급 업체

글로벌( 466)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Shanghai Worldyang Chemical Co.,Ltd.
+86-13651600618
CHINA 832 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

아세토페논 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved