diethyl benzylphosphonate
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diethyl benzylphosphonate 속성
- 끓는 점
- 106-108 °C1 mm Hg(lit.)
- 밀도
- 1.095 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.497(lit.)
- 인화점
- >230 °F
- 저장 조건
- Sealed in dry,Room Temperature
- 물리적 상태
- 액체
- Specific Gravity
- 1.10
- 색상
- 무색투명~미황색
- 수용성
- 물에 불용성.
- BRN
- 2580931
- CAS 데이터베이스
- 1080-32-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 | 36/38-36/37/38 | ||
---|---|---|---|
안전지침서 | 24/25-37-26 | ||
WGK 독일 | 3 | ||
RTECS 번호 | SZ6600000 | ||
TSCA | Yes | ||
HS 번호 | 29319090 |
diethyl benzylphosphonate C화학적 특성, 용도, 생산
화학적 성질
CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID용도
Diethyl benzylphosphonate is used as a reactant for synthesis of 3,5-dihydroxy-4-isopropylstilbene for treatment of skin disorders and natural cytotoxic marine products of polyketide origin via intramolecular Diels-Alder reactions. It is also used as reactant for cyclization of aryl ethers, amines and amides & for investigating the effects of functional groups on the performance of clue organic LEDs.제조 방법
Diethyl benzylphosphonate was synthesized according to the previously published procedure [1]. Benzylphosphonic acid (1 mmol, 172 mg) and triethyl orthoacetate (30 mmol, 5.5 mL) were mixed overnight at 90 °C. The completion of the reaction was monitored by 31P NMR. After the completion of the reaction, an excess of the orthoester was evaporated under reduced pressure. The crude product was purified via a short silica gel column (hexanes/ethyl acetate). The compound 1 was isolated as a transparent oil with 98% yield (0.98 mmol, 224 mg). 1H NMR (400 MHz, DMSO-d6) δ 7.39–7.14 (m, 5H), 3.94 (dq, JH-P = 7.9, JH-H = 7.0, 4H), 3.21 (d, JH-P = 21.6 Hz, 2H), 1.16 (t, JH-H = 7.0 Hz, 6H); 13C NMR (101 MHz, DMSO-d6) δ 132.3 (d, JC-P = 9.0 Hz), 129.7 (d, JC-P = 6.6 Hz), 128.2 (d, JC-P = 3.0 Hz), 126.4 (d, JC-P = 3.4 Hz), 61.3 (d, JC-P = 6.5 Hz), 32.3 (d, JC-P = 135.1 Hz), 16.1 (d, JC-P = 5.8 Hz); 31P NMR (162 MHz, DMSO-d6) δ 26.5. The NMR data are in accordance with those reported in literature [2].Synthesis Reference(s)
Tetrahedron Letters, 29, p. 1513, 1988 DOI: 10.1016/S0040-4039(00)80339-1Synthesis, p. 222, 1981 DOI: 10.1055/s-1981-29393
참고 문헌
[1] DAMIAN TRZEPIZUR. Selective Esterification of Phosphonic Acids.[J]. Molecules, 2021. DOI:10.3390/molecules26185637.[2] PETER J. THORNTON. Nucleoside Phosphate and Phosphonate Prodrug Clinical Candidates[J]. Journal of Medicinal Chemistry, 2016, 59 23: 10400-10410. DOI:10.1021/acs.jmedchem.6b00523.
[3] GASTON LAVEN. ChemInform Abstract: Preparation of Benzylphosphonates via a Palladium(0)-Catalyzed Cross-Coupling of H-Phosphonate Diesters with Benzyl Halides. Synthetic and Mechanistic Studies.[J]. ChemInform, 2010, 41 40. DOI:10.1002/chin.201040191.
[4] ANNA BRODZKA. The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents.[J]. Molecules, 2022. DOI:10.3390/molecules27206865.
diethyl benzylphosphonate 준비 용품 및 원자재
원자재
준비 용품
diethyl benzylphosphonate 공급 업체
글로벌( 199)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19536 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3002 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
diethyl benzylphosphonate 관련 검색:
PHENYLPHOSPHONIC ACID DIMETHYL ESTER
DIETHYL PHENYLPHOSPHONATE
DIETHYL 4-METHYLBENZYLPHOSPHONATE
DIETHYL(DIPHENYLMETHYL) PHOSPHATE
DIETHYL (4-BIPHENYLYLMETHYL)PHOSPHONATE
DIETHYL(4-NITROBENZYL)PHOSPHONATE
DIETHYL 4-AMINOBENZYLPHOSPHONATE
DIETHYL 4-METHOXYBENZYLPHOSPHONATE
diethyl benzylphosphonate
DIETHYL 1-NAPHTHYLMETHYLPHOSPHONATE
DIETHYL 4-CHLOROBENZYLPHOSPHONATE
BENZYLPHOSPHONIC ACID
DIETHYL (2-CHLORO-6-FLUOROBENZYL)PHOSPHONATE
DIETHYL(PHENYLOXOMETHYL)PHOSPHONATE
DIETHYL (ALPHA-AMINOBENZYL)PHOSPHONATE HYDROCHLORIDE
(2-METHYLBENZYL)PHOSPHONIC ACID DIETHYL ESTER
DIETHYL (2,6-DICHLOROBENZYL)PHOSPHONATE
DIETHYL HYDROXY(PHENYL)METHYLPHOSPHONATE