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L-(-)-트레오닌

L-(-)-트레오닌
L-(-)-트레오닌 구조식 이미지
카스 번호:
72-19-5
한글명:
L-(-)-트레오닌
동의어(한글):
2-아미노-3-하이드록시부탄산;L-(-)-트레오닌;트레오닌
상품명:
L-Threonine
동의어(영문):
THR;L-THR;H-THR-OH;Threonin;THREONINE;H-L-THR-OH;l-threonin;L-THREONINE;L-Threonone;L-Tlhreonine
CBNumber:
CB5702648
분자식:
C4H9NO3
포뮬러 무게:
119.12
MOL 파일:
72-19-5.mol

L-(-)-트레오닌 속성

녹는점
256 °C (dec.)(lit.)
알파
-28.4 º (c=6, H2O)
끓는 점
222.38°C (rough estimate)
밀도
1.3126 (rough estimate)
FEMA
4710 | L-THREONINE
굴절률
-28 ° (C=6, H2O)
저장 조건
Store at RT.
용해도
H2O: 50 mg/mL
물리적 상태
powder
산도 계수 (pKa)
2.09(at 25℃)
색상
Yellow
수소이온지수(pH)
5-6 (100g/l, H2O, 20℃)
optical activity
[α]20/D 28.5±0.5°, c = 5% in H2O
수용성
90 g/L (20 ºC)
JECFA Number
2119
Merck
14,9380
BRN
1721646
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
72-19-5(CAS DataBase Reference)
NIST
Threonine(72-19-5)
EPA
L-Threonine(72-19-5)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 24/25-37/39-26
WGK 독일 3
RTECS 번호 XO8590000
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29225000

L-(-)-트레오닌 MSDS


(2S,3R)-2-Amino-3-hydroxybutyric acid

L-(-)-트레오닌 C화학적 특성, 용도, 생산

화학적 성질

A white or almost white, crystalline powder or colourless crystals.

용도

amino acid, nutrient

용도

L-enantiomer

정의

ChEBI: An optically active form of threonine having L-configuration.

상표명

L -Threonine is JAN.

생명 공학 생산

L-Threonine can be produced using strains of E. coli or C. glutamicum. As threonine is also an amino acid of the aspartate family, aspartate semialdehyde is a common intermediate with the biosynthesis of L-lysine. In order to optimize a high-yielding L-threonine–producing strain, the following strategy is applied: the pathway towards L-lysine is minimized by reducing the activity of dihydrodipicolinate synthase (dapA) and at the same time the pathway towards L-threonine is favored by overexpression of the genes of the threonine operon, which consists of the genes for homoserine dehydratase (thrA), homoserine kinase (thrB), and threonine synthase (thrC). As L-threonine is also a precursor for L-isoleucine, further conversion of L-threonine into L-isoleucine has to be minimized by deactivation of the threonine dehydratase gene (ilvA). In the meantime, E. coli based strains have also been developed by the application of systems biology, not only by deletion or downregulation of the competing pathways such as L-lysine, L-methionine, and L-isoleucine, but also by optimization of the supply of key precursors such as oxaloacetate. The E. coli strain has been reported to produce 82 g/L L-threonine in 48 h with a carbon yield of 39 %. A more detailed description of the development of a commercial L-threonine process has been given by Debabov. Today L-threonine is manufactured on a commercial scale of several thousand tonnes using the E. coli fermentation process.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Likely impurities are allo-threonine and glycine. Crystallise L-threonine from H2O by adding 4volumes of EtOH. Dry and store it in a desiccator. It also crystallises from 80% EtOH to give hexagonal plates m 262-263o(dec). It sublimes at 200-226o/0.3mm with 99.6% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Elliot J Chem Soc 62 1950, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 1 pp 176-183, Vol 3 pp 2238-2257 1961, Beilstein 4 IV 3171.]

L-(-)-트레오닌 준비 용품 및 원자재

원자재

준비 용품


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