(1H-IMIDAZOL-4-YL)METHANAMINE

(1H-IMIDAZOL-4-YL)METHANAMINE 속성

(1H-IMIDAZOL-4-YL)METHANAMINE C화학적 특성, 용도, 생산

Synthesis

(1H-imidazol-4-yl)methanamine is prepared by adding hydroxylamine hydrochloride to a reaction mixture of 4-imidazolecarboxaldehyde, sodium carbonate and distilled water.
Experiment steps：Hydroxylamine hydrochloride (1.27 g, 18.3 mmol) was added to a reaction mixture of 4-imidazolecarboxaldehyde (800 mg, 8.3 mmol), sodium carbonate (445 mg, 4.2mmol) and distilled water (14 ml) and was left to react overnight at room temperature with stirring. The resultant mixture was then concentrated in vacuo to 3 ml and placed in an ice bath for precipitation to occur. Solid formed was collected by filtration, dissolved and recrystallized in ethanol to afford the colourless powder oxime, 1H-imidazole-4-carbaldehyde oxime (330 mg). Acetyl chloride (1.06 ml) was added dropwise into methanol (39 ml) in a round bottom flask at 0 °C under nitrogen purge and left to stir for 30 minutes. The oxime was then added into the reaction mixture followed by addition of palladium on carbon, 5% (296 mg, 2.40 mmol). The reaction mixture was hydrogenated at atmospheric pressure overnight. The resultant mixture was then filtered through celite pad, washed with methanol (30 ml) where the filtrate was then collected and concentrated in vacuo to give (1H-imidazol-4-yl)methanamine as a colourless powder (274 mg, 34%).

(1H-IMIDAZOL-4-YL)METHANAMINE 준비 용품 및 원자재

원자재

준비 용품

(1H-IMIDAZOL-4-YL)METHANAMINE 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5658	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	+86-029-86185165 +8618629664246	guoyuan@eastchinapharm.com	China	1615	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
SynAsst Chemical.	021-60343070		China	12742	55

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