ChemicalBook
Chinese English Japanese Germany Korea

쿠마린 4

쿠마린 4
쿠마린 4 구조식 이미지
카스 번호:
90-33-5
한글명:
쿠마린 4
동의어(한글):
쿠마린4;쿠마린4
상품명:
4-Methylumbelliferone
동의어(영문):
BMU;lm94;4-MU;LM 94;Medilla;Himecol;omega127;pilot447;NSC 9408;Bilcolic
CBNumber:
CB5745737
분자식:
C10H8O3
포뮬러 무게:
176.17
MOL 파일:
90-33-5.mol

쿠마린 4 속성

녹는점
188.5-190 °C(lit.)
끓는 점
267.77°C (rough estimate)
밀도
1.1958 (rough estimate)
굴절률
1.5036 (estimate)
저장 조건
-20°C Freezer
용해도
Solubility Practically insoluble in water; slightly soluble in ethanol, ether,chloroform; soluble inmethanol
산도 계수 (pKa)
7.79(at 25℃)
물리적 상태
Crystalline Powder
색상
off-white to yellow
pH 범위
Green 1 uorescent (0.0) to weak blue 1 uorescent (2.0);Weak blue 1 uorescent (6.5) blue 1 uorescent (8.0)
수용성
slightly soluble
최대 파장(λmax)
221nm, 251nm, 322nm
Merck
14,4854
BRN
142217
안정성
Stable. Combustible. Incompatible with strong oxidizing agents.
주요 응용
color filter, electroluminescent displays, document security processes, lasers, integrated circuits, liquid crystal displays, surface brightening composition, oil products, teeth whitening agent, lysosomal enzyme assay, substrate for lipase, determining protein-protein-interactions in living cells, Antitrypanosomal, antileishmanial, anticancer, antiHIV, antimalarial, antibacterial, antifungal
InChIKey
HSHNITRMYYLLCV-UHFFFAOYSA-N
CAS 데이터베이스
90-33-5(CAS DataBase Reference)
NIST
Coumarin, 7-hydroxy-4-methyl-(90-33-5)
EPA
4-Methylumbelliferone (90-33-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,Xn
위험 카페고리 넘버 36/37/38-20/21/22
안전지침서 26-37/39-36
WGK 독일 2
RTECS 번호 GN7000000
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29329990
독성 LD50 oral in rat: 3850mg/kg
기존화학 물질 KE-05-0742
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

쿠마린 4 MSDS


7-Hydroxy-4-methylcoumarin

쿠마린 4 C화학적 특성, 용도, 생산

화학적 성질

Off-White to Yellow Crystals

Originator

Odeston,Merck

용도

4-methylumbelliferone (4-MU) is a dietary supplement that inhibits hyaluronic acid (HA) synthesis. Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous malignancies. 4-MU is an already approved drug in Europe and Asia called “hymecromone” where it is used to treat biliary spasm.
4-Methylumbelliferone is useful as an indicator in the determination of nitric acid. It is also useful in the kinetic investigation of enzyme activity. 4-Methylumbelliferone is fluorescent in alkaline solution.

용도

Standard for the fluorometric determination of enzyme activity. Highly fluorescent in alkaline solution. Fluorescence: max Abs. l = 360nm, max. Em. l = 449nm; pH > 9

용도

choloretic, spasmolytic, sunscreen, Analytical reagent.

정의

ChEBI: A hydroxycoumarin that is umbelliferone substituted by a methyl group at position 4.

Manufacturing Process

Resorcin reacted with 3-oxo-butyric acid ethyl ester in the presence sulfuric acid and phosphorous pentaoxide and 4-methyl-7-hydroxycoumarine (hymecromone) was obtained.

Therapeutic Function

Choleretic, Spasmolytic, Sunscreen agent

일반 설명

Colorless crystals. Insoluble in water.

공기와 물의 반응

Insoluble in water.

화재위험

Flash point data for 4-Methylumbelliferone are not available. 4-Methylumbelliferone is probably combustible.

Pharmaceutical Applications

4-Methylumbelliferone is primarily used in synthesizing medicinal compounds and as a building block for fluorescent probes. Applications include synthesis of:
coumarin triazole derivatives as potential antimicrobial agents.
coumarin salen-based fluorescence sensors for Mg2+ detection.
pyranocoumarin derivatives as anti-hyperglycemic and anti-dyslipidemic agents.
coumarin piperazine derivatives as potential multireceptor atypical antipsychotics.
4-methylumbelliferyl T-antigen as a substrate for endo-α-N-acetylgalactosaminidase.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Purify it by recrystallisation from EtOH. It is very slightly soluble in cold H2O (solubility at 37o is 0.22%), slightly soluble in Et2O and CHCl3, but soluble in MeOH and AcOH. It has a blue fluorescence in aqueous EtOH and has UV: 221, max 251 and 322.5nm (MeOH). The IR has 3077 br, 1667, 1592, 1385, 1267, 1156, 1130 and 1066 cm-1.max The acetate has m 153-154o. [Woods & Sapp J Org Chem 27 3703 1962, Beilstein 18 III/IV 332, 18/1 V 439.]

쿠마린 4 준비 용품 및 원자재

원자재

준비 용품


쿠마린 4 공급 업체

글로벌( 415)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30037 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
QQ:800182836 stella@zetchem.com CHINA 2886 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10375 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 366 58

쿠마린 4 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved