HUMAN PDGF-BB

HUMAN PDGF-BB C화학적 특성, 용도, 생산

용도

Platelet-Derived Growth Factor-BB human has been used :

• As a growth supplement in proximal tubule and glomerular explant cell culture
• In three-dimensional scaffold preparation
• To study the effect of brivanib on growth factor signaling pathways
• In transwell migration assay

일반 설명

Platelet-derived growth factor (PDGF) is expressed as homo and heterodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD. The PDGF gene is highly conserved mapped to human chromosome 7p22.3. The active form of Pdgf exists as disulfide-linked dimers. It consists of cystine-knot-fold growth factor domain, which is highly conserved, except for the N-terminal prodomain, which shows variation in length among the isoforms.

Biochem/physiol Actions

The three naturally occurring PDGFs (platelet-derived growth factors); PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Heterozygous mutation in PDGFB is associated with primary familial brain calcification. It is also associated with angiogenesis for osteogenesis. PDGFB induces migration of endothelial progenitor cells and mesenchymal stem cells.

HUMAN PDGF-BB 준비 용품 및 원자재

원자재

준비 용품

HUMAN PDGF-BB 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Chengdu Jinglin Biotechnology Co., Ltd.	17711399154	3211919385@qq.com	China	1815	58
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696;	info@hanhongsci.com	China	42982	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
Chengdu Youngshe Chemical Co., Ltd.	028-62328193 17380623303	Caroline@youngshechem.com	China	2348	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19105	58
Shanghai Kanglang Biotechnology Co., Ltd.	021-61998208 18217752821	sales@klbio.cn	China	9617	58