CALCINEURIN
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CALCINEURIN 속성
- 저장 조건
- −20°C
- 용해도
- H2O: 용해성
- 물리적 상태
- 동결건조된 분말
안전
| 안전지침서 | 22-24/25 | ||
|---|---|---|---|
| WGK 독일 | 3 |
CALCINEURIN C화학적 특성, 용도, 생산
용도
Calcineurin from bovine brain has been used:- as a positive control in western blot analysis of oocytes and cumulus cells proteome
- as a positive control in calmodulin (CaM)-agarose binding assay
- to test its phosphatase activity in the presence of okadaic acid
일반 설명
Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain.Biochem/physiol Actions
Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.CALCINEURIN 준비 용품 및 원자재
원자재
준비 용품
CALCINEURIN 공급 업체
글로벌( 16)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
CALCINEURIN 관련 검색:
코발트(II) 아세틸아세토네이트 하이드레이트 알루미늄 아세틸아세토네이트 아세틸아세톤산 구리 실버 아세틸아세토네이트 아세틸아세토산 제2철 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트)
TERT-BUTYL ISOCYANIDE
Ethyl isocyanoacetate
METHYL ISOCYANOACETATE
Tris(2,4-pentanedionato)chroMiuM(III)
Tosylmethyl isocyanide
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
PHENYLSELENOL
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
Benzyl isocyanide
SALCOMINE
N-BUTYLISOCYANIDE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)