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다이에탄올아민

다이에탄올아민
다이에탄올아민 구조식 이미지
카스 번호:
111-42-2
한글명:
다이에탄올아민
동의어(한글):
2,2-이미노디에탄올(2,2-IMINODIETHANOL)디올아민;2,2-이미노비스(에탄올)(2,2-IMINOBIS(ETHANOL))이미노디에탄올;다이에탄올아민;다이에탄올아민(디에탄올아민);디에탄올아민;비스(2-히드록시에틸)아민(BIS(2-HYDROXYETHYL)AMINE)2,2-디히드록시디에틸아민(2,2-DIHYDROXYDIETHYLAMINE)디(2-히드록시에틸)아민(DI(2-HYDROXYETHYL)AMINE)2-((2-히드록시에틸)아미노)에탄올(2-((2-HYDROXYETHYL)AMINO)ETHANOL)비스(히드록시에틸)아민(BIS(HYDROXYETHYL)AMINE)N,N-디에탄올아민(N,N-DIETHANOLAMINE)B,B-디히드록시-디에틸아민(B,B-DIHYDROXY-DIETHYLAMINE)DI(BETA-HYDROXYETHYL)AMINE;2,2'-이미노비스-에탄올;2,2’악사네딜-b-에탄올;2,2'-다이하이드록시다이에틸아민;2,2'-이미노다이에탄올;다이(2-하이드록시에틸)아민;비스(2-하이드록시에틸)아민
상품명:
Diethanolamine
동의어(영문):
DEA;Aliphatic amine;Diolamine;Diethanolamin;dela;Iminodiethanol;2,2'-Azanediyldiethanol;2-(2-hydroxyethylamino)ethanol;2,2-IMINODIETHANOL;2,2'-DIHYDROXYDIETHYLAMINE
CBNumber:
CB5852839
분자식:
C4H11NO2
포뮬러 무게:
105.14
MOL 파일:
111-42-2.mol

다이에탄올아민 속성

녹는점
28 °C (lit.)
끓는 점
217 °C/150 mmHg (lit.)
밀도
1.097 g/mL at 25 °C (lit.)
증기 밀도
3.6 (vs air)
증기압
<0.98 atm ( 100 °C)
굴절률
n20/D 1.477(lit.)
인화점
280 °F
저장 조건
2-8°C
용해도
H2O: 1 M at 20 °C, clear, colorless
물리적 상태
Viscous Liquid or Low Melting Solid
색상
APHA: ≤15
Specific Gravity
1.09
수소이온지수(pH)
11.0-12.0 (25℃, 1M in H2O)
산도 계수 (pKa)
8.88(at 25℃)
냄새
Mild ammoniacal; faint, fishy; characteristic.
폭발한계
2.1-10.6%(V)
수용성
MISCIBLE
감도
Hygroscopic
최대 파장(λmax)
λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.02
Merck
14,3107
BRN
605315
노출 한도
TLV-TWA 3 ppm (~13 mg/m3) (ACGIH).
안정성
Stable. Incompatible with carbon dioxide, strong acids, strong oxidizing agents. Deliquescent.
InChIKey
ZBCBWPMODOFKDW-UHFFFAOYSA-N
CAS 데이터베이스
111-42-2(CAS DataBase Reference)
IARC
2B (Vol. 77, 101) 2013
NIST
Diethanolamine(111-42-2)
EPA
Diethanolamine (111-42-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-38-41-48/22
안전지침서 26-36/37/39-46
유엔번호(UN No.) 3267
WGK 독일 1
RTECS 번호 KL2975000
F 고인화성물질 3
자연 발화 온도 689 °F
TSCA Yes
포장분류 II
HS 번호 29221200
유해 물질 데이터 111-42-2(Hazardous Substances Data)
독성 LD50 orally in rats: 12.76 g/kg (Smyth)
기존화학 물질 KE-20959
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
예방조치문구:
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
NFPA 704
1
3 0

다이에탄올아민 C화학적 특성, 용도, 생산

개요

Diethanolamine is an organic base which has been used as an emulsifying and dispersing agent.It can also be used as a basic buffer, with optimal pH about pH 9, if titrated with HCl or other acid. Other uses include: to "scrub" gases, as a chemical intermediate, as humectant or softening agent.

화학적 성질

The USP32–NF27 describes diethanolamine as a mixture of ethanolamines consisting largely of diethanolamine. At about room temperature it is a white, deliquescent solid. Above room temperature diethanolamine is a clear, viscous liquid with a mildly ammoniacal odor.
diethanolamine
Diethanolamine is used as surface-active agent in metal-cutting fluids and oils, as a corrosion inhibitor, as a dispersant in agricultural chemical formulations, and as an intermediate in the production of other compounds such as fatty acid condensates of diethanolamine which are extensively used in soaps and cosmetics as emulsifiers, thickeners, wetting agents and detergents (Beyer et al., 1983). In the cosmetic formulations, the concentration of diethanolamine may range from 1 to 25% (National Toxicology Program, 1999a).

용도

Diethanolamine similar to triethanolamine (T775580) is used as a surfactant. It also has the potential to be a corrosion inhibitor by means of chemisorption.

정의

ChEBI: A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.

생산 방법

Diethanolamine is produced with monoethanolamine and triethanolamine by ammonolysis of ethylene oxide; diethanolamine is then separated by distillation (Mullins 1978). In 1984, 166.2 million pounds of diethanolamine were produced in the United States (USTIC 1985).

제조 방법

Diethanolamine is prepared commercially by the ammonolysis of ethylene oxide. The reaction yields a mixture of monoethanolamine, diethanolamine, and triethanolamine which is separated to obtain the pure products.

일반 설명

Oily colorless liquid or solid white crystals. Slight rotten fish or ammonia odor. Denser than water.

공기와 물의 반응

Water soluble.

반응 프로필

2,2'-Iminodiethanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 2,2'-Iminodiethanol is hygroscopic. 2,2'-Iminodiethanol may be sensitive to exposure to air and light. 2,2'-Iminodiethanol can react with oxidizing materials, acids, CO2, copper alloys, aluminum, zinc, galvanized iron and copper.

건강위험

The irritant action of diethanolamine on theeyes can be severe. Direct contact of thepure liquid can impair vision. Irritation onthe skin may be mild to moderate. Theacute oral toxicity of this compound waslow in test animals. The toxic symptomsinclude somnolence, excitement, and musclecontraction.
LD50 value, oral (mice): 3300 mg/kg
The vapor pressure of diethanolamine isnegligibly low (<0.01 torr at 20°C (68°F)).At ordinary temperature, this compoundshould not cause any inhalation hazard. Themists, fumes, or vapors at high temperatures,however, can produce eye, skin, and respiratory tract irritation.
In contrast to monoethanolamine, dieth anolamine administered to mice at 1125 mg/kg/day caused no change in maternal mortality, litter size, or percentage survival of thepups (Environmental Health Research andTesting 1987).

화재위험

Special Hazards of Combustion Products: Irritating vapors are generated when heated.

화학 반응

Reactivity with Water : No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Pharmaceutical Applications

Diethanolamine is primarily used in pharmaceutical formulations as a buffering agent, such as in the preparation of emulsions with fatty acids. In cosmetics and pharmaceuticals it is used as a pH adjuster and dispersant.
Diethanolamine has also been used to form the soluble salts of active compounds, such as iodinated organic acids that are used as contrast media. As a stabilizing agent, diethanolamine prevents the discoloration of aqueous formulations containing hexamethylenetetramine-1,3-dichloropropene salts.
Diethanolamine is also used in cosmetics.

색상 색인 번호

Diethanolamine is contained in many products, as a metalworking fuid. Traces may exist in other etha- nolamine-containing fuids.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Mildly toxic by skin contact. A severe eye and mild skin irritant. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, water, Co2, dry chemical. When heated to decomposition it emits toxic fumes such as NOx. See also AMINES.

잠재적 노출

Diethanolamine is present in machining and grinding fluids and has been detected in workplace air in the metal manufacturing industry. It was present in bulk cutting fluids at levels ranging from 4 to 5% (Kenyon et al., 1993). Diethanolamine has also been reported to be present in wetting fluids used in road paving. A level of 0.05 mg/m3 was detected in a stationary sample at a slurry machine discharging a bitumen emulsion containing 0.2% of the amine. All personal exposures were below the detection limit (0.02 mg/m3) (Levin et al., 1994). In a German study (1992–94), diethanolamine was measured in samples of metalworking fluids in a range of 0–44% (n = 69). The number of samples with diethanolamine present steadily declined from 90% to 60% over the study period (Pfeiffer et al., 1996).

Carcinogenicity

When DEA was administered cutaneously to pregnant rats and rabbits during organogenesis, developmental toxicity (skeletal variations) was observed only in the rat and only at doses causing significant maternal toxicity.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) is 3ppm (13mg/m3).

신진 대사

Treatment of Wistar or Sherman rats with diethanolamine caused increases in the formation of hepatic phospholipids (Artom et al 1949). In addition, dietary administration led to incorporation of ethanolamine into hepatic phospholipids (Artom et al 1949), and repeated oral administration of diethanolamine in drinking water (one to three wk) at a dose of 320 mg/kg/d was found to reduce the level of incorporation of ethanolamine and choline into hepatic and renal phospholipids in Sprague-Dawley rats (Barbee and H?rtung 1979b).
Dermal absorption of diethanolamine is suggested to occur in rats since Nnitrosodiethanolamine was excreted in the urine of male Sprague-Dawley rats which had been administered diethanolamine by dermal application and given nitrite in their drinking water (Preussman et al 1981).

저장

Diethanolamine is hygroscopic and light- and oxygen-sensitive; it should be stored in an airtight container, protected from light, in a cool, dry place.

운송 방법

UN2491 Ethanol amine or Ethanolamine solutions, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Fractionally distil the amine twice, then fractionally crystallise it from its melt. Its solubility in H2O is 10% at 20o. [Perrin & Dempsey Buffers for pH and Metal Ion Control Chapman & Hall, London 1974, Beilstein 4 H 283, 4 II 729, 4 III 689, 4 IV 1514.]

비 호환성

Diethanolamine is a secondary amine that contains two hydroxy groups. It is capable of undergoing reactions typical of secondary amines and alcohols. The amine group usually exhibits the greater activity whenever it is possible for a reaction to take place at either the amine or a hydroxy group.
Diethanolamine will react with acids, acid anhydrides, acid chlorides, and esters to form amide derivatives, and with propylene carbonate or other cyclic carbonates to give the corresponding carbonates. As a secondary amine, diethanolamine reacts with aldehydes and ketones to yield aldimines and ketimines. Diethanolamine also reacts with copper to form complex salts. Discoloration and precipitation will take place in the presence of salts of heavy metals.

폐기물 처리

Controlled incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV infusions, ophthalmic solutions, and topical preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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