라살로시드

라살로시드
라살로시드 구조식 이미지
카스 번호:
25999-31-9
한글명:
라살로시드
동의어(한글):
[2R-[2α[2S*(3R*,4S*,5S*,7R*)3S*,5S*],5α,6β]]-6-[7-[5-에틸-5-(5-에틸테트라하이드로-5-하이드록시-6-메틸-2H-피란-2-일)테트라하이드로-3-메틸-2-퓨릴]-4-하이드록시-3,5-다이메틸-6-오쏘노닐]-3-메틸살리실산;라살로시드;[2R-[2α[2S*(3R*,4S*,5S*,7R*)3S*,5S*],5α,6β]]-6-[7-[5-에틸-5-( 5-에틸테트라하이드로-5-하이드록시-6-메틸-2H-피란-2-일)테 트라하이드로-3-메틸-2-퓨릴]-4-하이드록시-3,5-다이메틸-6- 오쏘노닐]-3-메틸살리실산
상품명:
Lasalocid
동의어(영문):
Lasalocid;Aids003766;Lasalocid A;Aids-003766;Ionophore X-537A;Antibiotic X-537A;X 537A, Lasalocid A;Nsc243046 (sodium salt);25999-20-6 (Sodium salt);6-{7-[(5S)-5-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-5-ethyl-3-methyloxolan-2-yl](4S,5S,3R,7R)-4-hydroxy-3,5-dimethyl-6-oxononyl}-2-hydroxy-3-methylbenzoic acid
CBNumber:
CB5875179
분자식:
C34H54O8
포뮬러 무게:
590.79
MOL 파일:
25999-31-9.mol

라살로시드 속성

녹는점
110-114°; mp 100-109° (unsharp)
알파
D25 -7.55° (methanol)
끓는 점
735.7±60.0 °C(Predicted)
밀도
1.119±0.06 g/cm3(Predicted)
저장 조건
-20°C Freezer, Under inert atmosphere
용해도
아세토니트릴,(약간 용해됨), 메탄올(약간 용해됨, 초음파처리)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
3.15±0.39(Predicted)
색상
흰색에서 황백색까지

안전

독성 LD50 in mice (mg/kg): 40 i.p. (Berger); also reported as LD50 in mice (mg/kg): 146 orally, 64 i.p., J. W. Westley, "Antibiotics (Polyether)" in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 3 (Interscience, New York, 3rd ed., 1978) p 61
기존화학 물질 KE-05-0618
유해화학물질 필터링 97-1-57
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 라살로시드 염류 및 이를 2% 이상 함유한 혼합물

라살로시드 C화학적 특성, 용도, 생산

개요

Lasalocid is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. Lasalocid cytotoxicity targets cell metabolism, demonstrating EC50 values in the range of 7-20 μM in viability assays using chicken hepatoma LMH cells and rat myoblast L6 cells.

용도

Lasalocid is a polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine.

상표명

Avatec [as sodium] [Veterinary] (Hoffmann-LaRoche); Bovatec [as sodium] [Veterinary] (Hoffmann-LaRoche).

일반 설명

Lasalocid is one of the polyether ionophore antibiotics and was found in the culture broth of Streptomyces lasaliensis by Hoffmann-La Roche in 195. It shows activity against gram-positive bacteria, including Mycobacterium and Streptomyces, and also against anaerobic bacteria, but it has no activity against gramnegative bacteria or fungi. Lasalocid also shows strong anticoccidial activity, and it stimulates propionic acid formation in the rumen. It is used for prophylaxis and for therapy of coccidial infections in poultry and as a feed additive for growth promotion in cattle.

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