oleandomycin

oleandomycin 구조식 이미지
카스 번호:
3922-90-5
상품명:
oleandomycin
동의어(영문):
C01946;PA 775;PA-105;Romicil;Amimycin;Landomycin;oleandomycin;OleandoMycin A;Antibiotic PA-105;AMiMycin, MatroMycin, PA 105
CBNumber:
CB5928730
분자식:
C35H61NO12
포뮬러 무게:
687.86
MOL 파일:
3922-90-5.mol

oleandomycin 속성

녹는점
110 °C (decomp)
끓는 점
802.6±65.0 °C(Predicted)
밀도
1.21±0.1 g/cm3(Predicted)
저장 조건
-20°C Freezer
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)
pKa 8.84(H2O,t =25,I=0.167) (Uncertain)
물리적 상태
고체
물리적 상태
단단한 모양
색상
흰색에서 황백색까지

안전

유해 물질 데이터 3922-90-5(Hazardous Substances Data)
독성 LD50 orl-rat: 6700 mg/kg AMPMAR 39,259,1978

oleandomycin C화학적 특성, 용도, 생산

용도

Antibiotic substance produced by Streptomyces antibioticus no. ATCC 11891. Antibacterial.

Pharmaceutical Applications

A natural 14-membered-ring macrolide produced by Streptomyces antibioticus. It is stable in acid conditions. It is less active than erythromycin A in vitro, but four times more active than spiramycin . Several attempts have been made to improve its potency by chemical modification while retaining its relative acid stability.
It is incompletely absorbed, but an ester, triacetyloleandomycin, gives improved plasma levels. Following doses of 0.5 g, mean peak serum levels around 0.8 mg/L were reached by the base and 2 mg/L by the triacetyl ester. A single oral dose of 1 g of the ester produced a mean plasma oleandomycin concentration of 4 mg/L at 1 h after dosing, with an AUC of 14 mg.h/L. The apparent elimination half-life was 4.2 h. Significant quantities of mostly inactivated compound are eliminated in the bile. About 10% of the dose appears in the urine after administration of the base and about 20% after the ester.
Nausea, vomiting and diarrhea are common. Like erythromycin estolate, triacetyloleandomycin can cause liver damage. Abnormal liver function tests were found in about one-third of patients treated for 2 weeks. Hepatic dysfunction resolved when treatment was discontinued. The action of drugs eliminated via the cytochrome P450 system may be potentiated.
Its uses are similar to those of erythromycin. It is of restricted availability.

Safety Profile

A poison by intravenous route. Low toxicity by ingestion. When heated to decomposition it emits toxic vapors of NOx.

oleandomycin 준비 용품 및 원자재

원자재

준비 용품


oleandomycin 공급 업체

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