ChemicalBook >제품 카탈로그 >2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 구조식 이미지

카스 번호:: 302964-24-5

상품명:: 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

동의어(영문):: EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity 27;dasatinib interMediate;Dasatinib EP Impurity-A;2-AMino-N-(2-chloro-6-Meth

CBNumber:: CB61090897

분자식:: C11H10ClN3OS

포뮬러 무게:: 267.73

MOL 파일:: 302964-24-5.mol

속성

안전

용도

공급 업체 423

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 속성

녹는점: 208.0 to 212.0 °C

끓는 점: 362.0±37.0 °C(Predicted)

밀도: 1.474±0.06 g/cm3(Predicted)

저장 조건: under inert gas (nitrogen or Argon) at 2–8 °C

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: powder to crystal

산도 계수 (pKa): 11.09±0.70(Predicted)

색상: 흰색에서 밝은 노란색

InChI: InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16)

InChIKey: VVOXTERFTAJMAA-UHFFFAOYSA-N

SMILES: S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N

CAS 데이터베이스: 302964-24-5(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	29333990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330	입을 씻어내시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
1		0

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide C화학적 특성, 용도, 생산

Synthesis

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 준비 용품 및 원자재

원자재

벤젠 아민, 2- 클로로 -6- 메틸 - N-TRIPHENYLMETHYLTHIOUREA Ethyl 2-aminothiazole-5-carboxylate Dasatinib (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide 3-Ethoxyacryloyl chloride

준비 용품

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 다사티닙

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 공급 업체

글로벌( 423)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580 +86-18001856580	2415195517@qq.com	China	43	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7534	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 관련 검색:

에피클로로하이드린 N,N-다이메틸폼아마이드 노르말메틸포름아미드 글리신 클로로디플루오르메탄 클로로아세트산 Dasatinib Impurity 33 N-Deshydroxyethyl Dasatinib Dacomitinib (PF299804) Methyl 2-aminothiazole-5-carboxylate ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-5-CARBOXYLATE 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 2-Chloro-6-methylaniline (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Dasatinib monohydrate (E)-3-Ethoxyacryloyl chloride N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib