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에틸렌 클로로히드린

에틸렌 클로로히드린
에틸렌 클로로히드린 구조식 이미지
카스 번호:
107-07-3
한글명:
에틸렌 클로로히드린
동의어(한글):
2-클로로에탄올;에틸렌클로로하이드린;에틸렌클로로히드린;에틸렌클로로하이드린
상품명:
2-Chloroethanol
동의어(영문):
NCI-C50135;CH2ClCH2OH;Ghlorohydrin;Chloroethanol;2-CHLORETHANOL;2-Cloroetanolo;2-CHLOROETHANOL;2-Chloraethanol;2-Chloorethanol;Z-Chloroethanol
CBNumber:
CB6111920
분자식:
C2H5ClO
포뮬러 무게:
80.51
MOL 파일:
107-07-3.mol

에틸렌 클로로히드린 속성

녹는점
-63 °C
끓는 점
129 °C(lit.)
밀도
1.201 g/mL at 25 °C(lit.)
증기 밀도
2.78 (vs air)
증기압
5 mm Hg ( 20 °C)
굴절률
n20/D 1.441(lit.)
인화점
140 °F
저장 조건
2-8°C
용해도
Soluble in alcohol (Weast, 1986)
산도 계수 (pKa)
14.02±0.10(Predicted)
물리적 상태
Liquid
색상
Yellow
냄새
Faint, ethereal.
수용성
MISCIBLE
감도
Moisture Sensitive
Merck
14,3793
BRN
878139
노출 한도
Ceiling limit 3 mg/m3 (1 ppm) skin (ACGIH); TLV-TWA air 16 mg/m3 (5 ppm) skin (OSHA); IDLH 10 ppm (NIOSH).
안정성
Stable. Incompatible with oxidizing agents.
CAS 데이터베이스
107-07-3(CAS DataBase Reference)
NIST
Ethanol, 2-chloro-(107-07-3)
EPA
Ethanol, 2-chloro-(107-07-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T+,T,F
위험 카페고리 넘버 26/27/28-39/23/24/25-23/24/25-11-10
안전지침서 28-45-7/9-28A-36/37-16-7
유엔번호(UN No.) UN 1135 6.1/PG 1
WGK 독일 3
RTECS 번호 KK0875000
F 고인화성물질 21
TSCA Yes
위험 등급 6.1
포장분류 I
HS 번호 29333999
유해 물질 데이터 107-07-3(Hazardous Substances Data)
독성 LD50 orally in rats: 0.095 g/kg (Smyth)
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H226 인화성 액체 및 증기 인화성 액체 구분 3 경고
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 P264, P270, P301+P310, P321, P330,P405, P501
H310 피부와 접촉하면 치명적임 급성 독성 물질 - 경피 구분 1,2 위험 P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H330 흡입하면 치명적임 급성 독성 물질 흡입 구분 1, 2 위험 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
예방조치문구:
P320 긴급히 (…) 처치를 하시오.
P330 입을 씻어내시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P405 밀봉하여 저장하시오.

에틸렌 클로로히드린 MSDS


Ethylene chlorohydrin

에틸렌 클로로히드린 C화학적 특성, 용도, 생산

개요

Ethylene chlorohydrine is a clear, colourless liquid with mild, ethereal odour. It reacts with alkali metals. Ethylene chlorohydrine has applications as a laboratory reagent and as a pharmaceutical intermediate. Ethylene chlorohydrine is a building block in the production of pharmaceuticals, biocides, and plasticisers, used for manufacture of thiodiglycol, an important solvent for cellulose acetate and ethyl cellulose, textile-printing dyes, extraction of pine lignin, in dewaxing, refining of rosin, and the cleaning of machines. Several dyes are prepared by the alkylation of aniline derivatives with chloroethanol.

화학적 성질

Ethylene chlorohydrin is a colorless liquid with a faint, ethereal odor.

화학적 성질

colourless liquid

물리적 성질

Colorless liquid with a faint, ether-like odor. Odor threshold concentration is 400 ppb (quoted, Keith and Walters, 1992).

용도

Ethylene chlorohydrin is used in the manufacture of insecticides, as a solvent for cellu lose esters, in treating sweet potatoes beforeplanting (Merck 1989), and in making ethylene glycol and ethylene oxide. Exposurerisks to this compound may arise when itis formed from ethylene oxide during thesterilization of grain and spices, drugs, andsurgical supplies. The compound was used inthe past in hastening grape vine sprouting.

용도

2-Chloroethanol, is used in the preparation of TTFTT (tetrathiafulvalene-2,3,6,7-tetrathiolate) and important building block in TTF syntheis. In addition, it is used in the synthesis of vinyltriazoles. This is the labeled analog.

용도

Solvent; manufacture of insecticides; treating sweet potatoes before planting.

정의

ChEBI: A chloroethanol carrying a chloro substituent at position 2.

일반 설명

2-Chloroethanol is a colorless liquid with an ether-like odor. 2-Chloroethanol is soluble in water and is also a combustible liquid. It reacts with alkali metals.Ethylene chlorohydrine has applications as a laboratory reagent and as a pharmaceutical intermediate. Ethylene chlorohydrine is a building block in the production of pharmaceuticals, biocides, and plasticisers, used for manufacture of thiodiglycol, an important solvent for cellulose acetate and ethyl cellulose, textile-printing dyes, extraction of pine lignin, in dewaxing, refining of rosin, and the cleaning of machines. Several dyes are prepared by the alkylation of aniline derivatives with chloroethanol.

공기와 물의 반응

Highly flammable. 2-Chloroethanol is soluble in water.

반응 프로필

Mixing 2-Chloroethanol in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, ethylene diamine, and sodium hydroxide, [NFPA 1991]. Ethylenediamine reacts violently with 2-Chloroethanol. (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1554.).

위험도

Deadly via ingestion, inhalation, and skin absorption; strong irritant, penetrates ordinary rubber gloves and protective clothing. Moderate fire hazard. Questionable carcinogen.

건강위험

Ethylene chlorohydrin is a severe acute poi son. The target organs are CNS, cardiovascu lar system, kidney, liver, and gastrointestinalsystem. The symptoms of acute toxicity arerespiratory distress, paralysis, brain damage,nausea, and vomiting. In addition, ethylenechlorohydrin can cause glutathione depletionin liver and formation of polyuria in kidney.
Ingestion of 20–25 mL can be fatal tohumans. Death may occur in 48 hours dueto metabolic acidosis and respiratory failure.Ethanol therapy apparently produced no ben efit in treatment (Deng et al. 2001). It maybe more toxic by skin contact than by oralintake. Inhalation of its vapors can producenausea, vomiting, headache, chest pain, andstupor (ACGIH 1986). At high concentra tions, death may occur. Exposure to 300 ppmfor 2 hours can be fatal to humans.
LD50 value, oral (mice): 81 mg/kgLD50 value, intraperitoneal (mice): 97 mg/kg
Ethylene chlorohydrin is an irritant to theskin, eyes, nose, and mucous membranes.It is a confirmed mutagen by the Ames testin Salmonella typhimurium. It inhibits thegrowth of DNA-deficient bacteria. Exposureto this compound increased the chromosomeaberration in the bone marrow of rats. Theodor threshold is 0.4 ppm.
A 2-year dermal study showed no evidenceof carcinogenicity of ethylene chlorohydrin onrodents (NTP 2004). The compound, however,caused malformed fetus and maternal mortality in experimental animals.

건강위험

Very toxic; probable oral lethal dose in humans is 50-500 mg/kg or between 1 teaspoon and 1 ounce for a 70 kg (150 lb.) person. Poisoning causes liver and kidney degeneration and irritates mucous membranes; it may be cumulative. Several fatal cases with brain edema and lung edema have been reported from industrial exposure by inhalation and skin contact. It is more toxic by skin contact than orally.

화재위험

2-Chloroethanol decomposition products will react with water or steam to produce toxic and corrosive fumes of phosgene and hydrogen chloride. Vapors are heavier than air and may flash back to a source of ignition.

화학 반응

Reactivity with Water: No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

: A poison by ingestion, inhalation, skin contact, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic to humans by inhalation. It can affect the nervous system, liver, spleen, and lungs. An experimental teratogen. Mutation data reported. A severe eye and mild skin irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Violent reaction with chlorosulfonic acid, ethylene hamine, sodmm hydroxide. Reacts with water or steam to produce toxic and corrosive fumes. Potentially violent reaction with oxidizing materials. When heated to decomposition it emits highly toxic fumes of Cland phosgene. See also CHLORINATED HYDROCARBONS, ALIPHATIC.

잠재적 노출

Ethylene chlorohydrin is used as a solvent and emulsifier; in the synthesis of ethylene glycol, ethylene oxide, amines, carbitols, indigo, malonic acid, novocaine, and in other reactions where the hydroxyethyl group is introduced into organic compounds; for the separation of butadiene from hydrocarbon mixtures; in dewaxing and removing cycloalkanes from mineral oil; in the refining of rosin; in the manufacture of certain pesticides and in the extraction of pine lignin. In the lacquer industry, it is used as a solvent for cellulose acetate, cellulose esters, resins and waxes; and in the dyeing and cleaning industry, it is used to remove tar spots; as a cleaning agent for machines; and as a solvent in fabric dyeing. It has also found use in agriculture in speeding up sprouting of potatoes and in treating seeds to inhibit biological activity. Making chemical warfare agents

환경귀착

Biological. Heukelekian and Rand (1955) reported a 10-d BOD value of 0.50 g/g which is 50.0% of the ThOD value of 1.00 g/g.
Chemical/Physical. Reacts with aqueous sodium bicarbonate solutions at 105 °C producing ethylene glycol (Patnaik, 1992).

운송 방법

UN1135 Ethylene chlorohydrin, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone B

Purification Methods

Dry it with, then distil it from, CaSO4 in the presence of a little Na2CO3 to remove traces of acid. [Beilstein 1 IV 1372.]

비 호환성

May form explosive mixture with air. Strong oxidizers may cause fire and explosions. Incompatible with strong caustics (formation of ethylene gas), strong acids; alkaline metals; aliphatic amines; isocyanates. Violent reaction with ethylene diamine, chlorosulfonic acid. Attacks some plastics, rubber and coatings. Reacts with water or steam producing toxic and corrosive fumes

폐기물 처리

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

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