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실리빈

실리빈
실리빈 구조식 이미지
카스 번호:
22888-70-6
한글명:
실리빈
동의어(한글):
실리빈
상품명:
Silibinin
동의어(영문):
ybin;7c3mt;SILYBIN;Sylibin;Mepasil;Realsil;flavobin;silliver;silybine;Silymrin
CBNumber:
CB6112194
분자식:
C25H22O10
포뮬러 무게:
482.44
MOL 파일:
22888-70-6.mol

실리빈 속성

녹는점
164-174°C
알파
D20 +11° (c = 0.25 in acetone + alcohol)
끓는 점
793.0±60.0 °C(Predicted)
밀도
1.527±0.06 g/cm3(Predicted)
저장 조건
-20°C
산도 계수 (pKa)
pKa 6.42±0.04 (Uncertain)
수용성
54mg/L(24.99 ºC)
Merck
13,8607
안정성
Stable. Incompatible with strong oxidizing agents, strong bases.
CAS 데이터베이스
22888-70-6(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-37/39-24/25-22-36
유엔번호(UN No.) 3172
WGK 독일 3
RTECS 번호 DJ2981770
HS 번호 29329990
독성 LD50 intravenous in mouse: 1056mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

실리빈 C화학적 특성, 용도, 생산

화학적 성질

solid

Originator

Legalon,Madaus,W. Germany,1969

용도

Silibinin has been used:
  • to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR)
  • to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay
  • to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing
  • to study its inhibitory effect on Escherichia coli ATP synthase

용도

Labelled Silybin (S465850). Hepatoprotectant.

정의

ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.

Manufacturing Process

Silymarin comprising polyhydroxyphenyl chromanones is recovered from the dried fruit of Silybum marianum Gaertn. by separating the fatty oils therefrom, extracting the remaining solid residue with ethyl acetate, evaporating the ethyl acetate and dissolving the dry residue in a solvent mixture comprising methanol, water and petroleum ether to form a two-phase system wherein the chromanones are contained in the lower phase, recovering the polyhydroxyphenyl chromanones from the lower phase after subjecting same to multiple counter-current contact with petroleum ether.

Therapeutic Function

Hepatoprotectant

일반 설명

Silibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L).

Biochem/physiol Actions

Silibinin functions as a hepatoprotectant in patients with acute and chronic liver injury. This flavonoid fights against various cancer cells including, prostate, skin, breast, colon, lung, bladder and hepatocellular carcinoma (HCC). Silibinin exhibits its efficacy as an anti-cancer agent by blocking the secretion of proangiogenic factors from tumor cells, and by hindering growth and inducing apoptotic death of endothelial cells. In addition, it also interrupts capillary tube formation on Matrigel. Silibinin might be a good candidate for chemoprevention of prostate cancer (PC). It might be used as a potential therapeutic regimen for the treatment of endometriosis in vitro and in vivo.

실리빈 준비 용품 및 원자재

원자재

준비 용품


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