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페나세틴

페나세틴
페나세틴 구조식 이미지
카스 번호:
62-44-2
한글명:
페나세틴
동의어(한글):
페나세틴;펜아세틴
상품명:
Phenacetin
동의어(영문):
Soma;Kafa;Dasin;Tacol;Fenia;Malex;Viden;Xaril;Anapac;Phenin
CBNumber:
CB6141828
분자식:
C10H13NO2
포뮬러 무게:
179.22
MOL 파일:
62-44-2.mol

페나세틴 속성

녹는점
133-136 °C(lit.)
끓는 점
132 °C / 4mmHg
밀도
1.1248 (rough estimate)
굴절률
1.5710
인화점
2℃
저장 조건
2-8°C
물리적 상태
powder
산도 계수 (pKa)
pKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain)
색상
White
수용성
0.076 g/100 mL
감도
Hygroscopic
Merck
14,7204
BRN
1869238
안정성
Stable. Incompatible with strong oxidizing agents, strong acids.
InChIKey
CPJSUEIXXCENMM-UHFFFAOYSA-N
CAS 데이터베이스
62-44-2(CAS DataBase Reference)
NIST
Acetamide, N-(4-ethoxyphenyl)-(62-44-2)
EPA
Acetamide, N-(4-ethoxyphenyl)-(62-44-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,F
위험 카페고리 넘버 45-22-20/21/22-36-11
안전지침서 53-45-36/37-26-16
유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 3
RTECS 번호 AM4375000
TSCA Yes
HS 번호 29251995
유해 물질 데이터 62-44-2(Hazardous Substances Data)
독성 LD50 orally in rats: 1.65 g/kg (Boyd)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.

페나세틴 MSDS


4-Acetophenetidine

페나세틴 C화학적 특성, 용도, 생산

화학적 성질

Acetophenetidin is a fine, white, crystalline powder or solid. Odorless with a slightly bitter taste

용도

Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.

용도

glycosylation inhibitor

정의

ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.

상표명

[Names previously used: Acetophenetidin; Acetphenetidin.];292-comprimes 369, pulvules 3p bugesic;Acetylosal;Acifein;Acromas;Acropac;Algocratine;Alumidyne;Amypron;Amypylo-n;Angifebrine;Anodin;Antiflu des;Apadine;Apidin;Apracur;Arcin;Asceine;Ascophen;Ascthimindon;Asfeen;Ban-o-pain;Bexophene;Bromo quinina;Butal compound;Butorinal;Calmante muri;Capacetyl;Capramin;Caps dr knapp;Capsula dr. knapp;Ceachin;Cefinal;Cequinyl fort;Chloracet;Citramol;Codopyrin;Codral;Conta-schmerz;Coricidin f;Cotradol;Darvocomp-n;Darvon compuesto 65;Darvon n compuesto;Dentocaps;Dolafort;Dolomo;Doloxene comp forte, capsules;Dolviron;Doregrippin;Doscafis;Doviron;Drinacet;Estrifen;Femcaps;Fenascor;Fenbutal;Flexalgit;Florital;Fonal;Fridol;Friocellin;Funapann;Gripanidan;Harbureta;Hemagene taylor;Icn 65;Influenza tabs;Isollyl;Isomidon;Katagrip;Lekasin;Linarol;Manasul;Mardon;Migesic;Mironal;Monacet;Myolate;Neopyrine;Nevral vit b1 b6;Novacetol;Novosephalgin;Olfano;Omniadol;Papnin;Para-grip;Parametten;Pargesic compound;Pasadex;Pedigel;Phenacetine powder;Phenorial;Polypyrine;Poxy;Procomp-65;Prodigestan;Prodolor;Protension;Quadrochin;Rectoral;Refagan;Repro;Respritin;Rhinazol;Rinurel;Rinutan;Robaxisan-pm;Ron-drive;Rumicine;S antineuralgic;S fc;Sacadol;Sadaspir;Sedalmerck;Sk 65 compound caps.;Soma compound;Soma compuesto;Sonalgin;Spacin;Spasmindon;Spasmo-compralgyl;Synalogos-dc;T h;Tetrex-apc;Tetrracydin;Tiiomapirina;Tomapiena;Triplex;Uga-no;Vandar-65;Vasogesic;Vicks action 500;Zactirin compound-100.

World Health Organization (WHO)

Phenacetin, an aniline derivative, was introduced into medicine as an antipyretic over a century ago. It subsequently gained recognition as an analgesic and was available in many proprietary analgesic preparations. However, in the 1940s its habitual use was first implicated as the cause of methaemoglobinaemia and chronic haemolysis. Since 1950 there have been many reports published indicating that abusive use is associated with cumulative renal damage. Evidence also exists to suggest that it may have a carcinogenic potential. The drug has been withdrawn in many countries but may remain available in others. (Reference: (WHODI) WHO Drug Information, 1, 5, 1980)

일반 설명

Odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.

공기와 물의 반응

Insoluble in water.

반응 프로필

Phenacetin react with oxidizing agents, iodine and nitrating agents.

화재위험

Flash point data for Phenacetin are not available but Phenacetin is probably combustible.

Safety Profile

Confirmed carcinogen producing tumors of the lildney and bladder. A human poison by an unspecified route. Poison by intravenous and possibly other routes. Moderately toxic by several routes. Human systemic effects by ingestion: cyanosis, liver damage, and methemoglobinemiacarboxyhemo-globinemia. Experimental teratogenic data. Other experimental reproductive effects. Mutation data reported. Chronic effects consist of weight loss, insomnia, shortness of breath, weakness, and often aplastic anemia. When heated to decomposition it emits toxic fumes of NOx,.

잠재적 노출

Phenacetin is used as an analgesic and antipyretic drug. It is used alone or in combination with aspirin and caffeine for mild to moderate muscle pain relief. Phenacetin has also been used as a stabilizer for hydrogen peroxide in hair bleaching preparations. A laboratory reagent. In veterinary medicine; it is used as an analgesic and antipyretic.

Carcinogenicity

Phenacetin is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

운송 방법

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise it from H2O or EtOH, and its solubility in H2O is 0.08% (at ~10o) and 1.2% (at ~100o), and in EtOH it is 6.7% (at ~10o) and 36% (at ~100o). Alternatively it can be purified by solution in cold dilute alkali and re-precipitating by addition of acid to neutralisation point. Dry it in air. [Beilstein 13 H 461, 13 IV 1092.]

비 호환성

Oxidizing agents, iodine and nitrating agents.

폐기물 처리

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible, return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Permanganate oxidation, microwave plasma treatment, alkaline hydrolysis or incineration.

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