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에틸셀룰로스

에틸셀룰로스
에틸셀룰로스 구조식 이미지
카스 번호:
9004-57-3
한글명:
에틸셀룰로스
동의어(한글):
에틸셀룰로스;에틸셀룰로오스;에틸에테르셀룰로오스;에틸셀룰로오스에테르;에틸셀룰로스(ETHYLCELLULOSE)
상품명:
Ethyl cellulose
동의어(영문):
ets;g50;t100;g200;ethocel;spt50cps;nixone/c;aquacoat;ethocele7;ethoceln7
CBNumber:
CB6165620
분자식:
C23H24N6O4
포뮬러 무게:
448.47446
MOL 파일:
9004-57-3.mol

에틸셀룰로스 속성

녹는점
240-255 °C
밀도
1.14 g/mL at 25 °C (lit.)
굴절률
n20/D 1.47(lit.)
저장 조건
2-8°C
용해도
esters, aromatic hydrocarbons, alcohols and ketones: soluble
물리적 상태
powder
Specific Gravity
1.14
색상
White to slightly yellow
수용성
insoluble
Merck
14,3781
EPA
Ethyl cellulose (9004-57-3)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 1
RTECS 번호 FJ5950500
F 고인화성물질 3
자연 발화 온도 698 °F
TSCA Yes
HS 번호 39129000
유해 물질 데이터 9004-57-3(Hazardous Substances Data)
기존화학 물질 KE-13689

에틸셀룰로스 MSDS


Ethyl cellulose

에틸셀룰로스 C화학적 특성, 용도, 생산

화학적 성질

white to slightly yellowish powder

화학적 성질

Ethylcellulose is a tasteless, free-flowing, white to light tan-colored powder.

용도

ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose.

용도

Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates.

용도

In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder).

용도

Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit.

생산 방법

Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical:
RONa + C2H5Cl→ROC2H5+NaCl
The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three.

제조 방법

Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl.
Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures.

상표명

Aquacoat ECD (FMC);Ethocel (Dow Chemical).

Pharmaceutical Applications

Ethylcellulose is widely used in oral and topical pharmaceutical formulations.
The main use of ethylcellulose in oral formulations is as a hydrophobic coating agent for tablets and granules.Ethylcellulose coatings are used to modify the release of a drug, to mask an unpleasant taste, or to improve the stability of a formulation; for example, where granules are coated with ethylcellulose to inhibit oxidation. Modified-release tablet formulations may also be produced using ethylcellulose as a matrix former.
Ethylcellulose, dissolved in an organic solvent or solvent mixture, can be used on its own to produce water-insoluble films. Higher-viscosity ethylcellulose grades tend to produce stronger and more durable films. Ethylcellulose films may be modified to alter their solubility, by the addition of hypromellose or a plasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMC Biopolymer) or Surelease (Colorcon) may also be used to produce ethylcellulose films without the need for organic solvents. Drug release through ethylcellulose-coated dosage forms can be controlled by diffusion through the film coating. This can be a slow process unless a large surface area (e.g. pellets or granules compared with tablets) is utilized. In those instances, aqueous ethylcellulose dispersions are generally used to coat granules or pellets. Ethylcellulose-coated beads and granules have also demonstrated the ability to absorb pressure and hence protect the coating from fracture during compression.
High-viscosity grades of ethylcellulose are used in drug microencapsulation.
Release of a drug from an ethylcellulose microcapsule is a function of the microcapsule wall thickness and surface area.
In tablet formulations, ethylcellulose may additionally be employed as a binder, the ethylcellulose being blended dry or wetgranulated with a solvent such as ethanol (95%). Ethylcellulose produces hard tablets with low friability, although they may demonstrate poor dissolution.
Ethylcellulose has also been used as an agent for delivering therapeutic agents from oral (e.g. dental) appliances.
In topical formulations, ethylcellulose is used as a thickening agent in creams, lotions, or gels, provided an appropriate solvent is used. Ethylcellulose has been studied as a stabilizer for emulsions.
Ethylcellulose is additionally used in cosmetics and food products.

Safety Profile

Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes

Safety

Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys.
Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material.
As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet.
LD50 (rabbit, skin): >5 g/kg
LD50 (rat, oral): >5 g/kg

저장

Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters.
Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range.
Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents.

비 호환성

Incompatible with paraffin wax and microcrystalline wax.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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