펜타닐시트레이트
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펜타닐시트레이트 속성
- 녹는점
- 153-156°C
- 인화점
- 11 °C
- 저장 조건
- 2-8°C
- 용해도
- 물에 용해되고, 메탄올에 잘 용해되며, 에탄올에는 거의 용해되지 않습니다(96%).
- 물리적 상태
- 가루
- 색상
- 크리스탈
- 수용성
- Soluble to 40 mM in water
- CAS 데이터베이스
- 990-73-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 26/27/28-42/43-39/23/24/25-23/24/25-11-36/37 | ||
안전지침서 | 7-16-36/37-45-36/37/39-26 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UE5600000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 2933330000 | ||
독성 | LD50 in mice (mg/kg): 11.2 i.v.; 62 s.c. (Gardocki, Yelnosky) |
펜타닐시트레이트 C화학적 특성, 용도, 생산
화학적 성질
White Powder용도
Fentanyl citrate can be used as an analgesic.정의
ChEBI: The citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A mu-opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable canc r pain. It is also widely used as the analgesic component of balanced anaesthesia.생물학적 활성
Potent and selective μ -opioid receptor agonist (K i values are 7.0, 151 and 470 nM for μ -, δ - and κ -opioid receptors respectively). Displays antinociceptive activity in vivo .Clinical Use
A fentanyl patch is available for the treatment of severe chronic pain. This dosage form delivers fentanyl transdermally and provides effective analgesia for periods of up to 72 hours. In 1999, fentanyl also became available in a lollipop dose form for absorption from the oral cavity. Fentanyl's short duration of action after parenteral dose is caused by redistribution rather than by metabolism or excretion. Repeated doses of fentanyl can result in accumulation and toxicities. Elderly patients usually are more sensitive to fentanyl and require lower doses.Opioids have a wide spectrum of P-glycoprotein (P-gp) activity, acting as both substrates and inhibitors, which might contribute to their varying CNS-related effects. Although fentanyl, sufentanil, and alfentanil did not behave as P-gp substrates, they inhibited the in vitro P-gp–mediated efflux of drugs known to be P-gp transported, such as digoxin, increasing their blood levels and the potential for important drug interactions by inhibition of P-gp efflux transporter.
Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See also PHENTANYL.펜타닐시트레이트 준비 용품 및 원자재
원자재
준비 용품
펜타닐시트레이트 관련 검색:
드로페리돌, 펜타닐 구연산 나트륨, 무수 할로페리돌 시트르산(구연산) 칼슘시트레이트 프로피온아미드 시트르산암모늄
2-[5-(4-Chlorophenyl)pentyl]oxirane-2-carboxylic acid
Sildenafil citrate
Zinc citrate
PHENYL VALERATE
Mosapride citrate
N-(1-METHYLPIPERIDIN-4-YL)ANILINE
N-Phenyl-N-(4-piperidinyl)propanamide admixture with HCl salt
4-ACETAMIDOPIPERIDINE
1-Methyl-4-(methylamino)piperidine
Diphenoxylate
alfentanil