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NFPA 704
1
2
0
1-(2,3,4-트리메톡시벤질)피페라진 디하이드로클로라이드 C화학적 특성, 용도, 생산
개요
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
화학적 성질
Crystalline Solid
용도
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.