OXYPHENCYCLIMINE

OXYPHENCYCLIMINE 속성

OXYPHENCYCLIMINE C화학적 특성, 용도, 생산

용도

Oxyphencyclimine is widely used for the same indications as dicyclomine and oxybutynin.

일반 설명

Oxyphencycliminehydrochloride, 1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl -phenylcyclohexaneglycolate monohydrochloride(Daricon, Vistrax), was introduced in 1958 and promoted asa peripheral anticholinergic–antisecretory agent, with little orno curare-like activity and little or no ganglionic blocking activity.These activities are probably absent because of the tertiarycharacter of the molecule. This activity is in contrastwith that of compounds that couple antimuscarinic actionwith ganglionic blocking action. The tertiary character of thenitrogen promotes intestinal absorption of the molecule.Perhaps the most significant activity of this compound is itsmarked ability to reduce both the volume and the acid contentof the gastric juices, a desirable action in view of the more recenthypotheses pertaining to peptic ulcer therapy. Anotherimportant feature of this compound is its low toxicity in comparisonwith many of the other available anticholinergics.Oxyphencyclimine hydrochloride is hydrolyzed in the presenceof excessive moisture and heat. It is absorbed from theGI tract and has a duration of action of up to 12 hours.

Clinical Use

Oxyphencyclimine hydrochloride is suggested for usein peptic ulcer, pylorospasm, and functional bowel syndrome.It is contraindicated, as are other anticholinergics,in patients with prostatic hypertrophy and glaucoma.

Synthesis

Oxyphencylimine, the 1,4,5,6-tetrahydro-1-methyl-2-pyrimidinylmethanolic ester of |á-phenylcyclohexaneglycolic acid (14.1.37), is synthesized by the esterification of |á-phenyl-|á-cyclohexaneglycolic acid with 2-chloromethyl-1-methyl- 1,4,5,6-tetrahydropyrimidine (14.1.36) in the presence of potassium iodide. The initial 2-chloromethyl-1-methyl-1,4,5,6-tetrahydropyrimidine (14.1.36), is synthesized in turn by reacting methyl ester of iminochloracetic acid with 3-methylaminopropylamine [27¨C29].

OXYPHENCYCLIMINE 준비 용품 및 원자재

원자재

준비 용품

OXYPHENCYCLIMINE 공급 업체

공급자	전화	이메일	국가	제품 수	이점
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696;	info@hanhongsci.com	China	42982	64

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