4-Nitrophthalic anhydride
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4-Nitrophthalic anhydride 속성
- 녹는점
- 116-120 °C(lit.)
- 끓는 점
- 197 °C / 8mmHg
- 밀도
- 1.6392 (rough estimate)
- 굴절률
- 1.4700 (estimate)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 아세톤(약간), 클로로포름(약간), 메탄올(약간)에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 페일베이지
- 수용성
- 가수 분해
- 감도
- Moisture Sensitive
- BRN
- 179682
- CAS 데이터베이스
- 5466-84-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-20/22 | ||
| 안전지침서 | 26-36-36/37/39-22 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | TI3328000 | ||
| F 고인화성물질 | 10-21 | ||
| TSCA | Yes | ||
| HS 번호 | 29173990 |
4-Nitrophthalic anhydride C화학적 특성, 용도, 생산
화학적 성질
off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.용도
4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).제조 방법
4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.일반 설명
Yellow powder.공기와 물의 반응
Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.반응 프로필
4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.화재위험
Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.Purification Methods
Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]4-Nitrophthalic anhydride 준비 용품 및 원자재
원자재
준비 용품
4-Nitrophthalic anhydride 공급 업체
글로벌( 258)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Asia Chem I and E (Jiangsu) Co Ltd | +8615105181882 |
mera.z@nitrobenzenechemical.com | China | 129 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 12468 | 58 |
| Nantong Haigine Pharma Technology Co., Ltd | 0086-513-86266699 |
CHINA | 156 | 58 |