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Ganirelix

Ganirelix 구조식 이미지
카스 번호:
129311-55-3
상품명:
Ganirelix
동의어(영문):
Ganirelix USP/EP/BP;Ganirelix acetate salt;183552-38-7 (free base);Ganirelix Diacetate salt;GANIRELIX (ACETATE);183552-38-7 (FREE BASE);N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylaMino)Methylene]-D-lysyl-L-leucyl-N6-[bis(ethylaMino)Methylene]-L-lysyl-L-prolyl-;N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide diacetate
CBNumber:
CB62130570
분자식:
C80H113ClN18O13
포뮬러 무게:
1570.31902
MOL 파일:
129311-55-3.mol

Ganirelix 속성

저장 조건
-20°C
용해도
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
산도 계수 (pKa)
4.2 (3-pyridinylalanine); 9.8 (tyrosine)
물리적 상태
동결건조된 분말
색상
하얀색
InChIKey
GJNXBNATEDXMAK-PFLSVRRQSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
WGK 독일 3
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

Ganirelix C화학적 특성, 용도, 생산

개요

Ganirelix acetate was introduced in Germany as prefilled syringes for subcutaneous injections that inhibit premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation. This decapeptide analog of luteinizing hormonereleasing hormone (LH-RH) is the second third-generation LH-RH antagonist to be launched after citrorelix (Asta Medica). This highly bioavailable compound immediately blocks the endogenous release by the pituitary gland of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), the hormone that induces ovulation. After discontinuation of the treatment, the pituitary-gonadal function is rapidly recovered due to its short-half life. As a consequence, ganirelix at daily doses of 0.25 mg S.C. efficiently prevented LH surges during clinical trials in infertile women under controlled ovarian hyperstimulation with recombinant FSH before in vitro fertilization or similar reproductive techniques. Unlike first and second-generation gonadotropin-releasing hormone antagonists, ganirelix has minimal histamine-releasing effects thus avoiding the formation of edema of the face and extremities. Ganirelix is very resistant to hydrolysis and, in contrast to the already established cetrorelix, has good water solubility.

용도

Decapeptide LH-RH antagonist. Used in treatment of infertility.

Ganirelix 준비 용품 및 원자재

원자재

무수초산 1,3-디이소프로필 카보디아미드 트리플루오로아세트 산 1-하이드록시벤조트리아졸 일수화물

준비 용품

Ganirelix 공급 업체

글로벌( 66)공급 업체
공급자 전화 이메일 국가 제품 수 이점
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 contact@fuxinpharm.com China 10297 58
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marketing1@neostarunited.com China 8349 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5993 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167
 1026@dideu.com China 9553 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29474 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9571 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 +86-13986145403
 info@fortunachem.com China 5985 58
Wuhan wingroup Pharmaceutical Co., Ltd 		+86-13296627870; +8613296627870
 info@whwingroup.com China 703 58

Ganirelix 관련 검색:

VAPREOTIDE Eledoisin Eptifibatide Acetate Leuprorelin acetate Nafarelin Acetate Triptorelin acetate Secretin Acetate Desmopressin ARG-LYS-GLU-VAL-TYR ACETATE SALT Teriparatideacetate Pramlintide acetate Teriparatide acetate Angiotensin acetate Lixisenatide Ganirelix Acetate elagolix Relugolix Abarelix
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