염산 메트포르민
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염산 메트포르민 속성
- 녹는점
- 223-226 °C(lit.)
- 밀도
- 1.36[at 20℃]
- 증기압
- 0.001Pa at 25℃
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 용해도
- 물에 잘 녹고, 알코올에 약간 녹고, 아세톤과 염화메틸렌에는 거의 녹지 않습니다.
- 산도 계수 (pKa)
- 12.4[at 20 ℃]
- 물리적 상태
- 가루
- 색상
- 하얀색
- 수용성
- 물(50mg/ml), 에탄올 및 DMSO(50mM)에 용해됩니다.
- 최대 파장(λmax)
- 233nm(H2O)(lit.)
- Merck
- 14,5938
- BCS Class
- 3
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 증류수 용액은 -20°에서 최대 2개월 동안 보관할 수 있습니다.
- InChIKey
- OETHQSJEHLVLGH-UHFFFAOYSA-N
- LogP
- -3.5 at 20℃
- CAS 데이터베이스
- 1115-70-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/38-39/23/24/25-23/24/25-11 | ||
안전지침서 | 26-36-45-36/37-16-7 | ||
유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
WGK 독일 | 3 | ||
RTECS 번호 | DU1800000 | ||
HS 번호 | 29252900 | ||
유해 물질 데이터 | 1115-70-4(Hazardous Substances Data) | ||
독성 | LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin) |
염산 메트포르민 C화학적 특성, 용도, 생산
개요
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.화학적 성질
Crystalline Solid용도
Metformin hydrochloride may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations and human plasma samples by analytical techniques.정의
ChEBI: A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride.일반 설명
1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base. It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes. Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug. Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method. Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans.생물학적 활성
Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.염산 메트포르민 준비 용품 및 원자재
원자재
준비 용품
염산 메트포르민 공급 업체
글로벌( 891)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
Auschemicals Pty Ltd | +61406202619 |
info@auschemicals.com | Australia | 431 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 |
hbjbtech@163.com | China | 1000 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 |
admin@hbsaisier.cn | China | 747 | 58 |
염산 메트포르민 관련 검색:
다이사이안 다이아미드 디메틸아민 6-아미노-1,3,5-트라이아진-2,4(1H,3H)-다이온 염산 메트포르민
Dimethylamine hydrochloride
N,N-DiMethylaMidino) Urea
Metformin Impurity 3 HCl
Calcium cyanamide
Demiditraz IMpurity
Demiditraz
METHYL-D3-AMINE HYDROCHLORIDE
Metformin Impurity 16
MetforMin IMpurity E Sulfate
(4,6-DIAMINO-1,3,5-TRIAZINE-2-YL)GUANIDINE
Metformin Impurity 7
1-METHYLBIGUANIDE SULPHATE
N4-methyl-1,3,5-triazine-2,4,6-triamine
N,N-Dimethylcarbamic acid