알루미늄수크로오스옥타설페이트

알루미늄수크로오스옥타설페이트
알루미늄수크로오스옥타설페이트 구조식 이미지
카스 번호:
54182-58-0
한글명:
알루미늄수크로오스옥타설페이트
동의어(한글):
알루미늄수크로오스옥타설페이트
상품명:
Sucralfate
동의어(영문):
SUCRALPHATE;carafate;Keal;Ulcar;Urbal;Sugast;Venter;Citogel;Succosa;Sucrate
CBNumber:
CB6239042
분자식:
C11H52Al16O75S8-16
포뮬러 무게:
2072.71
MOL 파일:
54182-58-0.mol

알루미늄수크로오스옥타설페이트 속성

녹는점
>220°C (dec.)
끓는 점
1990℃ at 101.325kPa
밀도
0.338 at 20℃
증기압
0Pa at 25℃
저장 조건
Inert atmosphere,2-8°C
용해도
물, 에탄올(96%) 및 염화메틸렌에는 거의 녹지 않습니다. 무기산과 알칼리성 수산화물의 묽은 용액에 용해됩니다.
산도 계수 (pKa)
pKa = 0.43 to 1.19(at 25℃)
색상
하얀색
LogP
1.46 at 25℃ and pH7

안전

WGK 독일 2
RTECS 번호 BD0900000
HS 번호 29400090
유해 물질 데이터 54182-58-0(Hazardous Substances Data)

알루미늄수크로오스옥타설페이트 MSDS


Sucralfate

알루미늄수크로오스옥타설페이트 C화학적 특성, 용도, 생산

개요

Sucralfate is a complex of the sulfuric acid ester of sucrose and aluminum hydroxide. Secondary polymerization with aluminum hydroxide forms intermolecular bridges between molecules of sulfate esters with aluminum. Limited dissociation of the complex occurs in gastric acid, but these anionic sulfate esters form insoluble adherent complexes with the proteinaceous exudate at the abraded surface of a crater of the ulcerated area in the stomach. This physical complex protects the ulcer from the erosive action of pepsin and bile salts. Sucralfate also stimulates synthesis and release of prostaglandins, bicarbonate, and epidermal and fibroblast growth factors. Significant ulcer healing effects are noted in placebo-controlled trials. Only small amounts of sucralfate are absorbed systemically. In renal impairment, there is a risk of accumulation of absorbed aluminum from the drug. Sucralfate reduces absorption of other drugs, including H2 antihistamines, quinolone antibiotics, phenytoin, and perhaps, warfarin

화학적 성질

White Powder

용도

Sucralfate, an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication. Bis- and tris-platinum complexes of sucrose show promise as antitumor agents. Sucrose monoesters are used in some pharmaceutical preparations.

Indications

Sucralfate (Carafate) is an aluminum hydroxide–sulfated sucrose complex that is only minimally absorbed from the GI tract. After exposure to gastric acid, the compound becomes negatively charged, creating a viscous adherent complex. This complex is believed to inhibit back-diffusion of H .Other effects are a direct reduction in pepsin activity and a slight rise in tissue prostaglandin levels. Stimulation of a cytoprotection mechanism may therefore assist mucosal healing. The drug has no acid-buffering capacity.

일반 설명

Sucralfate, 3,4,5,6-tetra-(polyhydroxyaluminum)-α-D-glucopyranosyl sulfate-2,3,4,5-tetra-(polyhydroxyaluminum)-β-D-fructofuranoside sulfate (Carafate), isthe aluminum hydroxide complex of the octasulfate ester ofsucrose. It is practically insoluble in water and soluble instrong acids and bases. It has a pKa value between 0.43 and1.19.
Sucralfate is minimally absorbed from the GI tract by design,and thus exerts its antiulcer effect through local ratherthan systemic action. It has negligible acid-neutralizing orbuffering capacity in therapeutic doses. Although its mechanismof action has not been established, studies suggestthat sucralfate binds preferentially to the ulcer site to form aprotective barrier that prevents exposure of the lesion to acidand pepsin. In addition, it adsorbs pepsin and bile salts.Either would be very desirable modes of action.
The simultaneous administration of sucralfate may reducethe bioavailability of certain agents (e.g., tetracycline, phenytoin,digoxin, or cimetidine). It further recommends restorationof bioavailability by separating administration of theseagents from that of sucralfate by 2 hours. Presumably, sucralfatebinds these agents in the GI tract. The most frequentlyreported adverse reaction to sucralfate is constipation (2.2%).Antacids may be prescribed as needed but should not be takenwithin 0.5 hour before or after sucralfate.

Clinical Use

Sucralfate is frequently used for prophylaxis of stress-induced gastritis in patients in intensive care units. It has also been successfully used in small numbers of patients as a suspension enema to treat radiation proctitis.

알루미늄수크로오스옥타설페이트 준비 용품 및 원자재

원자재

준비 용품


알루미늄수크로오스옥타설페이트 공급 업체

글로벌( 267)공급 업체
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Henan Tianfu Chemical Co.,Ltd.
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info@tianfuchem.com China 21700 55
career henan chemical co
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sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8823 58
BOC Sciences
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inquiry@bocsci.com United States 19553 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com China 2530 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
CHINA 968 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290
1056@dideu.com China 3959 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58

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