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Dabigatran etexilate

Dabigatran etexilate 구조식 이미지

카스 번호:: 211915-06-9

상품명:: Dabigatran etexilate

동의어(영문):: DL-;BIBR-1048;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridyl-beta-alanine,ethyl ester;Etexilate;Dabigatran ester;BIBR-1048 (Dabigatran);N-[2-[4-[N-(Hexyloxycarbonyl)aMidino]phenylaMinoMethyl]-1-Methyl-1H-benziMidazol-5-ylcarbonyl]-N-(2-;CS-62;Prazaxa;BIBR 1048

CBNumber:: CB62485052

분자식:: C34H41N7O5

포뮬러 무게:: 627.73

MOL 파일:: 211915-06-9.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 417

Dabigatran etexilate 속성

녹는점: 128-129°

밀도: 1.24±0.1 g/cm3(Predicted)

저장 조건: Sealed in dry,Store in freezer, under -20°C

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

산도 계수 (pKa): 9.88±0.46(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 연한 노란색

안정성: 흡습성

안전

Dabigatran etexilate C화학적 특성, 용도, 생산

개요

Dabigatran etexilate is an orally administered pro-drug of dabigatran, which is a direct inhibitor of thrombin and a potent anticoagulant. The serine protease thrombin is the final mediator in the coagulation cascade that leads to the production of fibrin, the main protein component of blood clots. Thrombin is also a potent activator of platelets. Consequently, thrombin inhibitors have found utility as anticoagulants in treating arterial and venous thrombosis. Warfarin, although orally available, has a narrow therapeutic index and requires frequent monitoring and dosage adjustment. Low-molecular-weight heparins provide better safety profile and less inter-patient variability; however, these agents are only available for parenteral administration. Direct thrombin inhibitors (DTIs) are a new class of anticoagulants that act by directly binding to thrombin at its catalytic or fibrinogen-binding sites, or both. Unlike the heparins, DTIs do not require the activation of secondary factors such as antithrombin to derive their activity, which makes their action more predictable. In addition, their ability to inhibit both free and clot-bound thrombin predisposes them for enhanced anticoagulation effect.

용도

Dabigatran Etexilate is an oral anticoagulant and direct thrombin inhibitor.

정의

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amino group of thyl N-pyridin-2-yl-beta-alaninate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.

Dabigatran etexilate 준비 용품 및 원자재

원자재

C3-NITRO-4-METHYLAMINO-BENZOYLCHLORIDE 클로로포름산노르말헥실에스테르 4-(METHYLAMINO)-3-NITROBENZOIC ACID 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate Dabigatran iMpurity O ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE

준비 용품

Dabigatran Impurity 8 Dabigatran Etexilate Mesylate

Dabigatran etexilate 공급 업체

글로벌( 417)공급 업체

공급자	전화	이메일	국가	제품 수	이점
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15932	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9346	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Dabigatran etexilate 관련 검색:

N-헥실 클로로포메이트 Rivaroxaban Dabigatran Dabigatran Etexilate Mesylate 3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrroloidine-L-(+)-tartarate Chloroacetic anhydride 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Dabigatran Etexilate iMpurity D Dabigatran iMpurity E Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity) Dabigatran iMpurity F Pravastatin sodium Bortezomib Imatinib mesylate Panobinostat Torin 1