PF-04457845
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PF-04457845 속성
- 끓는 점
- 687.0±55.0 °C(Predicted)
- 밀도
- 1.389±0.06 g/cm3(Predicted)
- 저장 조건
- room temp
- 용해도
- DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
- 산도 계수 (pKa)
- 12.72±0.20(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전
WGK 독일 | 3 |
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PF-04457845 C화학적 특성, 용도, 생산
Biochem/physiol Actions
PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.PF-04457845 준비 용품 및 원자재
원자재
Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1)
Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester
CarbaMic acid, N-3-pyridazinyl-, phenyl ester
벤젠메탄올,3-[[5-(트리플루오로메틸)-2-피리디닐]옥시]-
Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)-
3-히드록시벤질 알콜
2-클로로-5-(트리플루오로메틸)피리딘
준비 용품
PF-04457845 공급 업체
글로벌( 72)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10991 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |