Mefloquine hydrochloride
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Mefloquine hydrochloride 속성
- 녹는점
- 250-254?C
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 38mg/mL, 가용성
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- 최대 파장(λmax)
- 222nm(Acidic H2O)(lit.)
- Merck
- 14,5801
- BCS Class
- 4/2
- 안정성
- 온도에 민감함
- InChI
- InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
- InChIKey
- WESWYMRNZNDGBX-YLCXCWDSSA-N
- SMILES
- C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
- CAS 데이터베이스
- 51773-92-3(CAS DataBase Reference)
Mefloquine hydrochloride MSDS
(2R)-(+/-)-alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
Mefloquine hydrochloride C화학적 특성, 용도, 생산
개요
Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.화학적 성질
White Solid용도
Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.일반 설명
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standardsClinical Use
The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.
Mefloquine hydrochloride 준비 용품 및 원자재
원자재
준비 용품
Mefloquine hydrochloride 공급 업체
글로벌( 248)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Porton Pharma Solutions Ltd. | |
China | 56 | 58 | |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
Mefloquine hydrochloride 관련 검색:
염산톨페리존 퀸하이드론 플루퀸코나졸 에톡시퀸 로퍼라미드 하이드로클로라이드 이소퀴놀린 3,7-디클로로-8-퀴놀린카복실산 염산디펜히드라민 할로페리돌 드로페리돌, 펜타닐 메페리딘 수화염화물
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