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포도뿌리추출물

포도뿌리추출물
포도뿌리추출물 구조식 이미지
카스 번호:
84929-27-1
한글명:
포도뿌리추출물
동의어(한글):
포도뿌리추출물;포도씨추출물;포도잎추출물;포도추출물
상품명:
Grape Seed Extract
동의어(영문):
GSE;Grape skin;GRAPE SEED;NataPres GS;Grape seed dry;Unii-T3pw93ib4q;Grape, red, ext.;Proanthocyanidin;GRAPELEAFEXTRACT;Einecs 284-511-6
CBNumber:
CB6258001
분자식:
C32H30O11
포뮬러 무게:
590.574
MOL 파일:
84929-27-1.mol

포도뿌리추출물 속성

안전

포도뿌리추출물 C화학적 특성, 용도, 생산

화학적 성질

Grape seed extract has an astrigent taste.

Composition

Standardized grape seed extracts are reported to contain 74 to 78% oligomeric proanthocynidins and less than approx- imately 6% of free favanol monomers on a dry weight basis Specifcally, grape seed extract contains the favanol monomers (+)-cat- echin, (–)-epicatechin, (–)-epicatechin gallate, (–)-epigallocatechin and (–)-epigallocatechin gallate.

Anticancer Research

Grape seed extract (GSE) has high quantities of proanthocyanidins and resveratrol.Human colorectal cancer cell (CRC) exposure to GSE (Schonthal 2012) resulted inmodified ER chaperones glucose-related protein-78 (GRP78) and protein disulphideisomerase (PDI). GRP78 is needed for integrity of ER as well as stress-inducedautophagy (Flaumenhaft et al. 2015). PDI, a thiol-disulphide oxidoreductase,catalyses the disulphide bonds in newly synthesized proteins in the ER lumen (Hanet al. 2013; Wang and Kaufman 2014; Perri et al. 2016), and PDIA3 is localized tothe ER and is involved in protein folding (Wang et al. 2012b). Studies on the role ofPDI in cancer have demonstrated a pro-oncogenic, pro-survival role for PDI incancer and therapeutic resistance. PDI aids in ameliorating stress-induced apoptosisand causes degradation of wrongly folded proteins (Dinicola et al. 2010; Xu et al.2014). Hence, any obstruction caused in the activity of PDI will induce stress in thecell and lead to cell apoptosis. Fructose bisphosphate aldolase, a key enzymeinvolved in glycolysis, is also a potential target of GSE (Vandewynckel et al. 2016).The ER stress leads the cell to undergo apoptotic pathways in multiple ways andhence inhibits the proliferation of the targeted cells (Farooqi et al. 2015).

포도뿌리추출물 준비 용품 및 원자재

원자재

준비 용품


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