ChemicalBook
Chinese English Japanese Germany Korea

NIFE디솔

NIFE디솔
NIFE디솔 구조식 이미지
카스 번호:
21829-25-4
한글명:
NIFE디솔
동의어(한글):
NIFE디솔;니페디핀
상품명:
Nifedipine
동의어(영문):
Orix;ADALAT;Anifed;Oxcord;ADALATE;CITILAT;NIFELAT;bay1040;Nifedin;Nifelan
CBNumber:
CB6260129
분자식:
C17H18N2O6
포뮬러 무게:
346.33
MOL 파일:
21829-25-4.mol

NIFE디솔 속성

녹는점
171-175 °C
끓는 점
481.08°C (rough estimate)
밀도
1.2109 (rough estimate)
굴절률
1.5486 (estimate)
저장 조건
2-8°C
용해도
DMSO: soluble
물리적 상태
powder
산도 계수 (pKa)
pKa -0.9/>13(DMF,t undefined) (Uncertain)
색상
yellow
수용성
<0.1 g/100 mL at 19.5 ºC
Merck
14,6528
InChIKey
CYCWGQFQPAYBHG-UHFFFAOYSA-N
CAS 데이터베이스
21829-25-4(CAS DataBase Reference)
NIST
Nifedipine(21829-25-4)
EPA
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate (21829-25-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/37/38
안전지침서 26-36
WGK 독일 1
RTECS 번호 US7975000
위험 등급 IRRITANT
HS 번호 29333990
유해 물질 데이터 21829-25-4(Hazardous Substances Data)
독성 LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)
기존화학 물질 KE-10622
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P330 입을 씻어내시오.

NIFE디솔 MSDS


Nifedipine

NIFE디솔 C화학적 특성, 용도, 생산

화학적 성질

Yellow Crystalline Solid

Originator

Adalat,Bayer,W. Germany,1975

용도

Used as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker

용도

Nifedipine is used for preventing and relieving angina pectoris attacks, for hypertension, and as an ingredient in combination therapy for chronic cardiac insufficiency.

용도

For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

Manufacturing Process

45 grams 2-nitrobenzaldehyde, 80 cc acetoacetic acid methyl ester, 75 cc methanol and 32 cc ammonia are heated under reflux for several hours, filtered off, cooled and, after suction-filtration, 75 grams of yellow crystals of MP 172° to 174°C are obtained, according to US Patent 3,485,847.

상표명

Adalat (Bayer); Afeditab (Watson);Procardia (Pfizer).

Therapeutic Function

Coronary vasodilator

World Health Organization (WHO)

Nifedipine is a dihydropyridine calcium channel blocker. It is listed in the WHO Model List of Essential Drugs. The 10mg tablet is retained on the list for short-term treatment of hypertension. Sustained-release preparations are advised for long-term treatment.

일반 설명

Nifedipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate dimethyl ester(Adalat, Procardia), is a dihydropyridine derivative thatbears no structural resemblance to the other calcium antagonists.It is not a nitrate, but its nitro group is essential for itsantianginal effect. As a class, the dihydropyridines possessa central pyridine ring that is partially saturated. To this, positions2 and 6 are substituted with an alkyl group that mayplay a role in the agent’s duration of action. In addition, positions3 and 5 are carboxylic groups that must be protectedwith an ester functional group. Depending on the type ofester used at these sites, the agent can be distributed to variousparts of the body. Finally, position 4 requires an aromaticsubstitution possessing an electron-withdrawinggroup (i.e., Cl or NO2) in the ortho and/or meta position.

일반 설명

Odorless yellow crystals or powder. Tasteless.

공기와 물의 반응

Aqueous solutions are very sensitive to light. . Insoluble in water.

반응 프로필

Nifedipine is sensitive to light.

화재위험

Flash point data for Nifedipine are not available; however, Nifedipine is probably combustible.

생물학적 활성

L-type calcium channel blocker.

Biochem/physiol Actions

Nifedipine is a L-type Ca2+ channel blocker; and induces apoptosis in human glioblastoma cells. Nifedipine has neuroprotection activity and protects substantia nigra. Nifedipine has antioxidant potential. Nifedipine downregulates inflammatory cytokines like macrophage inflammatory protein-2 (MIP-2), tumor necrosis factor-α (TNF-α). Nifedipine has antihypertensive properties. Nifedipine inhibits extracellular region of adenosine A2a receptor (ADORA2A) gene.

Mechanism of action

Nifedipin causes relaxation of smooth musculature, dilation of coronary and peripheral arteries, and reduction of peripheral resistance and arterial blood pressure, and enhances oxygen supply to the heart.

Clinical Use

The prototype of this class, nifedipine, has potent peripheralvasodilatory properties. It inhibits the voltage-dependentcalcium channel in the vascular smooth muscle but has littleor no direct depressant effect on the SA or AV nodes, eventhough it inhibits calcium current in normal and isolated cardiactissues. Nifedipine is more effective in patients whoseanginal episodes are caused by coronary vasospasm and isused in the treatment of vasospastic angina as well as classicangina pectoris. Because of its strong vasodilatory properties,it is used in selected patients to treat hypertension.

Chemical Synthesis

Nifedipine, dimethyl ether 1,4-dihydro-2,6-dimethyl-4-(2′-nitrophenyl)-3,5- piridindicarboxylic acid (19.3.16), is synthesized by a Hantsch synthesis from two molecules of a β-dicarbonyl compound—methyl acetoacetate, using as the aldehyde component— 2-nitrobenzaldehyde and ammonia. The sequence of the intermediate stages of synthesis has not been completely established.

NIFE디솔 준비 용품 및 원자재

원자재

준비 용품


NIFE디솔 공급 업체

글로벌( 497)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Univar Solutions(China) Co., Ltd.
15902132654
86-21-61932700 Ivy.zhuang@univarsolutions.com CHINA 295 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9165 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3284 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com China 2008 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58

NIFE디솔 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved