As a starting material to synthesize N,N′-dimethyl-6-amino uracil.
In combination with β-cyclodextrin derivatives, to form low melting mixtures (LMMs), which can be used as solvents for hydroformylation and Tsuji-Trost reactions.
To synthesize N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones via Biginelli condensation under solvent-free conditions.
정의
ChEBI: A member of the class of ureas that is urea substituted by methyl groups at positions 1 and 3.
일반 설명
Colorless crystals.
공기와 물의 반응
Water soluble.
반응 프로필
1,3-Dimethylurea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
건강위험
ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-Dimethylurea emits toxic fumes.
화재위험
Flash point data for 1,3-Dimethylurea are not available; 1,3-Dimethylurea is probably combustible.
Safety Profile
Moderately toxic by
intraperitoneal route. Experimental
teratogenic and reproductive effects. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of NOx
Purification Methods
Crystallise the urea from acetone/diethyl ether by cooling in an ice bath. Also crystallise it from EtOH and dry it at 50o/5mm for 24hours [Bloemendahl & Somsen J Am Chem Soc 107 3426 1985]. [Beilstein 4 IV 207.]
