2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
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2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 속성
- 녹는점
- 67-69°C
- 끓는 점
- 360.8±52.0 °C(Predicted)
- 밀도
- 1.33±0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- -8.49±0.20(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 황백색에서 밝은 노란색까지
- InChI
- InChI=1S/C7H10N2O2S/c1-2-12(10,11)9-5-7(6-9)3-4-8/h3H,2,5-6H2,1H3
- InChIKey
- HQUIOHSYUKWGOM-UHFFFAOYSA-N
- SMILES
- C(#N)/C=C1\CN(S(CC)(=O)=O)C\1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2933998090 |
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| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile C화학적 특성, 용도, 생산
용도
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile is an intermediate in the synthesis of Baricitinib, a JAK 1 and 2 inhibitor used in the treatment of rheumatoid arthritis.Synthesis
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is synthesized by first treating azetidine-3-ol hydrochloride with an equimolar equivalent of an alkanesulfonyl chloride, preferably ethanesulfonyl chloride, to give l-ethylsulfonylazetidin-3-ol. Preferably, the reaction is performed in a biphasic solution comprising a mixture of an organic phase and a aqueous phase, preferably THF with an aqueous solution which is basic, while maintaining the solution at room temperature or a temperature slightly below room temperature, preferably 20 °C. The reaction is followed to completion using standard monitoring techniques. Typically, the reaction is complete within 1 to 5 hours. The organic layer is removed, preferably by distillation, and the aqueous layer is extracted with an appropriate solvent such as toluene, p-cymene, and CPME. Preferably the extraction solvent is toluene. Alternatively, the toluene extractions can be excluded if recrystallization of 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is performed.
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 준비 용품 및 원자재
원자재
준비 용품
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 공급 업체
글로벌( 258)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 |
chang@shjlchem.com | China | 20 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 |
info@millionpharm.com | China | 154 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 906 | 58 |