4-히드록시페닐아세트산
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4-히드록시페닐아세트산 속성
- 녹는점
- 148-151 °C(lit.)
- 끓는 점
- 234.6°C (rough estimate)
- 밀도
- 1.2143 (rough estimate)
- 증기압
- 0.007Pa at 25℃
- 굴절률
- 1.4945 (estimate)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 50g/L
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 4.50±0.10(Predicted)
- 색상
- 흰색에서 크림색 또는 밝은 황갈색
- 수소이온지수(pH)
- 2.0-2.4 (30g/l, H2O, 20℃)
- 수용성
- 디메틸설폭사이드와 메탄올에 용해됩니다. 물에 약간 용해됩니다.
- BRN
- 1448766
- InChIKey
- XQXPVVBIMDBYFF-UHFFFAOYSA-N
- LogP
- 0.75 at 25℃
- CAS 데이터베이스
- 156-38-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36-24/25 | ||
WGK 독일 | 3 | ||
RTECS 번호 | AI2680000 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29182990 |
4-히드록시페닐아세트산 C화학적 특성, 용도, 생산
화학적 성질
4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics.용도
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.제조 방법
4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid.4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.
정의
ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.Purification Methods
Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]4-히드록시페닐아세트산 준비 용품 및 원자재
원자재
글리옥살
페놀
4-Aminophenylacetic acid
글리옥실산
벤질2-(4-(벤질록시)페닐)아세테이트
4-Iodophenylacetic acid
2-(4-히드록시페닐)에탄올
메틸4-클로로페닐아세테이트
4-히드록시페닐아세토니트릴
4-메톡시페닐초산
2-하이드록시-1-(4-하이드록시페닐)에타논
3,4-Dihydroxyphenylacetic acid
4-Vinylphenol
준비 용품
4-히드록시페닐아세트산 공급 업체
글로벌( 729)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2990 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 |
sales@richfortunechem.com | China | 304 | 57 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9357 | 55 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |