ChemicalBook >제품 카탈로그 >(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 구조식 이미지

카스 번호:: 1448189-80-7

상품명:: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

동의어(영문):: VHL Ligand 1;ULM-1;ULM-1(MDK7526HCL);VHL Ligand 1 HCl salt;141003;CS-2718;ULM-1 HCl;UBI-10003;MDK7526 HCl;MDK-7526;ULM-1

CBNumber:: CB63156669

분자식:: C22H31ClN4O3S

포뮬러 무게:: 467.03

MOL 파일:: 1448189-80-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 139

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 속성

저장 조건: 2-8°C

용해도: DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

물리적 상태: 결정성 고체

InChIKey: JYRTWGCWUBURGU-XIMRXPCLNA-N

SMILES: C([C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1.Cl |&1:1,3,9,r|

안전

HS 번호	2934100090

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride C화학적 특성, 용도, 생산

개요

VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Item No. 21622).

용도

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 준비 용품 및 원자재

원자재

준비 용품

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 공급 업체

글로벌( 139)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Suzhou Origin Specialty Chemicals Co., Ltd.	+86-512-68662322 +86-17312436797	hanqun@origsc.com	China	733	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3000	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	331	58
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 관련 검색:

Cereblon Ligand 1 4-Hydroxy ThalidoMide Protein degrader 1 (TFA) 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-