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글루타티온

글루타티온
글루타티온 구조식 이미지
카스 번호:
70-18-8
한글명:
글루타티온
동의어(한글):
글루타티온
상품명:
Glutathione
동의어(영문):
GSI;GSH;-GL;LGB-GT;copren;glutide;tathion;panaron;neuthion;isethion
CBNumber:
CB6320803
분자식:
C10H17N3O6S
포뮬러 무게:
307.32
MOL 파일:
70-18-8.mol

글루타티온 속성

녹는점
192-195 °C (dec.) (lit.)
알파
-16.5 º (c=2, H2O)
끓는 점
754.5±60.0 °C(Predicted)
밀도
1.4482 (rough estimate)
굴절률
-17 ° (C=2, H2O)
저장 조건
2-8°C
용해도
H2O: 50 mg/mL
물리적 상태
powder
산도 계수 (pKa)
pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
색상
White
수소이온지수(pH)
3 (10g/l, H2O, 20°C)
냄새
Odorless
수용성
soluble
Merck
14,4475
BRN
1729812
안정성
Stable. Incompatible with strong oxidizing agents.
InChIKey
RWSXRVCMGQZWBV-WDSKDSINSA-N
CAS 데이터베이스
70-18-8(CAS DataBase Reference)
EPA
Glutathione (70-18-8)
안전
  • 위험 및 안전 성명
위험품 표기 Xi
위험 카페고리 넘버 68-36/37/38
안전지침서 24/25-36/37/39-27-26
WGK 독일 2
RTECS 번호 MC0556000
F 고인화성물질 9-23
TSCA Yes
HS 번호 29309070
기존화학 물질 KE-17781
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
NFPA 704
0
1 0

글루타티온 MSDS


5-L-Glutamyl-L-cysteinylglycine

글루타티온 C화학적 특성, 용도, 생산

용도

자연계에 널리 분포하여 동물, 효소 등 거의 모든 생체 내의 산화환원반응에 중요한 역할을 한다. 일부 미생물의 성장인자이고, 효소 글리옥살라아제의 조효소이며, 또 SH기를 가진 효소(카텝신 등)의 활성화에도 관여한다.

개요

Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

화학적 성질

White cryst. powder

Originator

L-Glutathione,Solgar,USA

용도

Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons

용도

glutathione is a peptide composed of cysteine, glycine, and glutamate. It is believed to enhance the skin’s cellular metabolism and oxygen utilization. It has been found to protect the fibroblast against free radical-induced oxidation and act as a powerful antioxidant. Studies indicate that it can inactivate the tyrosinase enzyme and quench free radicals that contribute to tyrosinase and melanin formation, thereby serving as a skin-lightening or de- pigmenting agent. glutathione is a component of plant and animal tissue, naturally occurring in the body and essential for the proper functioning of the immune system.

용도

L-Glutathione is used in the treatment of lung diseases for patients who are HIV positive. It protects the cancerous cells by conferring resistance to chemotherapeutic drugs. It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. As an antioxidant, it prevents damage to important cellular components that arise due to reactive oxygen species like free radicals and peroxide. It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca2+ ions. It is also used in white wine production.

정의

ChEBI: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.

Manufacturing Process

The tripeptide thiol glutathione (L-γ-glutamyl-L-cysteinyl-glycine (GSH)) found in virtually all cells functions in metabolism, transport and cellular protection.
Glutathione may be obtained from an yeast or synthetically.
A yeast containing 600 parts of yeast solids is heated just to the boiling point of water. The yeast solids are removed by centrifuging or filtration. Sulphuric acid is added to the filtrate to give 0.5 N strength as sulphuric acid 6 parts of ascorbic acid are added. Then 2 parts of cuprous oxide are added with stirring. The reaction mixture is then centrifuged and washed until the precipitate is free from sulphates. The precipitate is suspended in 100 parts of water and hydrogen sulfide is bubbled through the water until all of the copper is precipitated as copper sulphide. The filtrate is evaporated and the glutathione is purified by recrystallization from 50% ethanol. All parts are by weight.
The preparation of glutathion by methods of peptide synthesis is expansive and gives 20-30% yield of GHS. For the first time synthetic glutathion was prepared by M. Bergmann et al.

Therapeutic Function

Anabolic, Antidote

일반 설명

Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signaling and protection against oxidative stress.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Safety Profile

Moderately toxic by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Purification Methods

Crystallise L-glutathione from 50% aqueous EtOH, dry it in a vacuum and

글루타티온 준비 용품 및 원자재

원자재

준비 용품


글루타티온 공급 업체

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