ISOTETRANDRINE

ISOTETRANDRINE 구조식 이미지
카스 번호:
477-57-6
상품명:
ISOTETRANDRINE
동의어(영문):
NSC 97338;isosinomenina;ISOTETRANDRINE;isosinomeninea;1-isotetrandrine;O-METHYLBERBAMINE;(r,s)-tetrandrine;1-Isotetrandrine(8CI);o,o’-dimethylobamegine;BERBAMINE METHYL ETHER
CBNumber:
CB6376880
분자식:
C38H42N2O6
포뮬러 무게:
622.76
MOL 파일:
477-57-6.mol

ISOTETRANDRINE 속성

녹는점
180-182℃
끓는 점
710.5±60.0 °C(Predicted)
밀도
1.172
RTECS 번호
NX7285000
용해도
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
물리적 상태
회백색 고체.
산도 계수 (pKa)
7.70±0.20(Predicted)

안전

ISOTETRANDRINE C화학적 특성, 용도, 생산

개요

A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]17D + 146° or[α]20D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.

용도

Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

참고 문헌

Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
Synthesis:
Inubushi et ai., Tetrahedron Lett., 3399 (1968)

ISOTETRANDRINE 준비 용품 및 원자재

원자재

준비 용품


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