QUINOMYCIN A
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QUINOMYCIN A 속성
- 녹는점
- 217-218℃
- 알파
- D20 -310° (c = 0.86 in chloroform)
- 끓는 점
- 1427.2±65.0 °C(Predicted)
- 밀도
- 1.0964 (rough estimate)
- 굴절률
- 1.6700 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMSO에 용해됨(최대 5mg/ml)
- 산도 계수 (pKa)
- 9.38±0.70(Predicted)
- 물리적 상태
- 흰색 고체
- 색상
- 흰색에서 베이지색
- Merck
- 13,3531
- 안정성
- 공급된 대로 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 46-23/24/25 | ||
안전지침서 | 53-36/37/39-45 | ||
유엔번호(UN No.) | UN 3462 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | JW5250000 | ||
F 고인화성물질 | 10 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 2941900000 |
QUINOMYCIN A C화학적 특성, 용도, 생산
개요
Hypoxia-용도
Quiniomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumour agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumour progression and metastasis.Biochem/physiol Actions
Echinomycin is an antitumor antibiotic and potent hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the binding of HIF-1α, a transcription factor important in tumor growth. Echinomycin selectively eliminated cancer stem cells in a study with mouse lymphoma and human AML xenogeneic models, eradicating the lymphomas. Recently, echinomycin was also found to act as an antibiotic adjuvant having synergistic effects with novobiocin in gram negative bacteria.QUINOMYCIN A 준비 용품 및 원자재
원자재
준비 용품
QUINOMYCIN A 공급 업체
글로벌( 63)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 |
wendy@huidabiotech.com | CHINA | 87 | 58 |
BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
QUINOMYCIN A 관련 검색:
Chrysin
Anifostine trihydrate
CHAETOMIN
BISPHENOL A DIMETHYL ETHER
Sunitinib Malate
Geldanamycin
Imatinib mesylate
Azithromycin
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
2-QUINOXALINECARBALDEHYDE
AC-VAL-OME
QUINOMYCIN A
DIMETHYLAMINOETHOXY PROPYLAMINE
quinomycin
N,N-DIMETHYL-L-VALINE
2-QUINOXALINYLMETHYLAMINE,97%
2-Quinoxalinemethanamine,N-methyl-(9CI)
3-[(3-AMINO-3-OXOPROPYL)THIO]PROPANAMIDE