란소프라졸
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란소프라졸 속성
- 녹는점
- 178-182°C dec.
- 끓는 점
- 555.8±60.0 °C(Predicted)
- 밀도
- 1.50±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 물에 거의 녹지 않으며, 무수 에탄올에 녹고, 아세토니트릴에는 아주 약간 녹습니다.
- 산도 계수 (pKa)
- pKa 2.34±0.37 (Occasionally);3.53±0.37 (Occasionally);8.48±0.30 (Occasionally)
- 물리적 상태
- 가루
- 색상
- 회백색
- Merck
- 14,5362
- BCS Class
- 2
- InChIKey
- MJIHNNLFOKEZEW-UHFFFAOYSA-N
- CAS 데이터베이스
- 103577-45-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | DD9487500 | ||
| HS 번호 | 29339900 | ||
| 유해 물질 데이터 | 103577-45-3(Hazardous Substances Data) | ||
| 독성 | dog,LD,oral,> 2gm/kg (2000mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 387, 1993. |
란소프라졸 C화학적 특성, 용도, 생산
개요
Lansoprazole is the second proton pump inhibitor approved as an antiulcer agent for the short term treatment of duodenal ulcer and gastroesophageal reflux disease. Like omeprazole, lansoprazole is reported to be more efficacious than the H2-antagonists in treating peptic ulcer disease.Other potential uses could be in the treatment of Zollinger-Ellison syndrome.화학적 성질
White Crystalline Powder용도
Used as a gastric proton pump inhibitor. An antiulcerative일반 설명
Lansoprazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole(Prevacid), is a white to brownish white, odorless crystallinepowder that is practically insoluble in water.Lansoprazole is a weak base (pyridine N, pKa 3.83.) and aweak acid (benzimidazole N-H, pK 0.62). Like other PPIs,lansoprazole is essentially a prodrug that, in the acidic biophaseof the parietal cell, forms an active metabolite thatirreversibly interacts with the target ATPase of the pump.Lansoprazole must be formulated as encapsulated entericcoatedgranules for oral administration to protect the drugfrom the acidic environment of the stomach.In the fasting state, about 80% of a dose of lansoprazole(vs. 50% of omeprazole) reaches the systemic circulation,where it is 97% bound to plasma proteins. Thedrug is metabolized in the liver (sulfone and hydroxymetabolites) and excreted in bile and urine, with a plasmahalf-life of about 1.5 hours.
생물학적 활성
H + ,K + -ATPase inhibitor (IC 50 = 6.3 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.09 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro . Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole ).란소프라졸 준비 용품 및 원자재
원자재
무수초산
tert-부틸알코올
Methanol solution of sodium methoxide
오산화 바나듐
아세트산(빙초산)
2,3-Lutidine
2-메르캅토 벤즈이미다졸
염화 티오닐
트리페닐포스핀
디에틸 아조디카복실산
테트라뷰틸암모늄 클로라이드
차아염소산나트륨
준비 용품
란소프라졸 공급 업체
글로벌( 899)공급 업체
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|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
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| Sigma Audley | +86-18336680971 +86-18126314766 |
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| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Jiangsu Zhongbang Pharmaceutical Co., Ltd. | 025-87151996 |
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| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
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| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
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| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
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| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |