(-)-COTININE
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(-)-COTININE 속성
- 녹는점
- 40-42 °C(lit.)
- 끓는 점
- 250 °C150 mm Hg(lit.)
- 알파
- [α]D20 -18~-22° (c=1, C2H5OH)
- 밀도
- 1.1102 (rough estimate)
- 굴절률
- 1.7110 (estimate)
- 인화점
- >230 °F
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- 클로로포름(소량으로 용해), DMSO(약간 용해됨), 메탄올(소량으로 용해)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.72±0.12(Predicted)
- 색상
- 무색~매우 진한 주황색 오일
- optical activity
- [α]/D -21±2°, c = 1 in ethanol
- 수용성
- 물에 섞이거나 혼합하기 어렵지 않습니다. 디메틸 설폭사이드(100mM), 에탄올(50mg/ml, 투명하고 희미한 노란색에서 노란색 용액 생성), 메탄올 및 클로로포름에 용해됩니다.
- Merck
- 14,2553
- BRN
- 83099
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다. 열에 민감할 수 있으므로 차갑게 보관하세요.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-39/23/24/25-23/24/25-11 | ||
안전지침서 | 7-16-36/37-45-36-26 | ||
유엔번호(UN No.) | UN 1230 3/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | GN1925500 | ||
F 고인화성물질 | 10 | ||
HS 번호 | 29333990 | ||
유해 물질 데이터 | 486-56-6(Hazardous Substances Data) |
(-)-COTININE C화학적 특성, 용도, 생산
개요
Cotinine is the major metabolite of nicotine. In the liver, nicotine is rapidly metabolized to cotinine (70–80%) by CYP2A6 and to nornicotine (5%) by CYP2A6 and CYP2B6. With a half-life about 10-fold longer than that of nicotine (15–19 h for cotinine versus 2–3 h for nicotine), cotinine induces plasma concentrations of 1–3 mM in smokers. After administration to rats, cotinine levels in the brain reach fourfold those of nicotine at 4 h following injection. Cotinine is not biotransformed in the brain, allowing accumulation of this substance to levels greater than that of nicotine.Like nicotine, cotinine is able to induce dopamine release in smokers and in superfused rat striatal slices in a dose- and calcium-dependent manner via the nicotinic receptors, but only at concentrations higher than those normally seen in smokers. Indeed, administration of cotinine to smokers at levels 10-fold that is seen following smoking had no observable effect, suggesting that cotinine is not neuroactive at doses found in smokers. However, cotinine also acts as an inhibitor for nicotine binding in rat brain via desensitization of the nicotinic receptor.
화학적 성질
Colourless to Light Brown Solid용도
(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.정의
ChEBI: An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.생물학적 활성
Major metabolite of nicotine. Shown to activate a subpopulation of α 3/ α 6 β 2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo .환경귀착
Cotinine stimulates dopamine release in the nigrostriatal pathway by activating nicotinic acetylcholine receptors. However, its lower EC50 prevents significant activation of this pathway in smokers.(-)-COTININE 준비 용품 및 원자재
원자재
준비 용품
(-)-COTININE 공급 업체
글로벌( 134)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
sgtlifesciences pvt ltd | +8617013299288 |
dj@sgtlifesciences.com | China | 12382 | 58 |
Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
(-)-COTININE 관련 검색:
칼륨 크롬산(III) 황산염 십이수화물 황산칼륨
(-)-COTININE
DL-COTININE-D3 (N-METHYL-D3),COTININE-METHYL-D3, 99 ATOM % D,(+/-)-COTININE-D3,COTININE-D3 (N-METHYL-D3)
DL-Cotinine-methyl-D3,DL-COTININE-D3 (N-METHYL-D3),COTININE-METHYL-D3,COTININE-D3 (N-METHYL-D3),(+/-)-COTININE-D3
TRANS-3'-HYDROXYCOTININE-O-B-D-GLUCURONIDE
TICRYNAFEN
(3'R,5'S)-3'-HYDROXYCOTININE
TRANS-3'-HYDROXYCOTININE, METHYL-D3
Oxybutynin
CARBOXY COTININE
CHROMIUM POTASSIUM SULFATE
ChroMiuM(III) sulfate hydrate
ALPHA-PYRIDOIN
TRANS-3'-HYDROXYCOTININE-N-BETA-D-GLUCURONIDE, METHYL-D3
N-(4-METHOXYBENZYL)COTININE
1-(4-METHOXYBENZYL)-3-ACETOXYNORCOTININE
CNG