메틸글루카민
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메틸글루카민 속성
- 녹는점
- 129-131.5 °C (lit.)
- 끓는 점
- 331.88°C (rough estimate)
- 알파
- -16.5 º (c=10, H2O, on dry sub)
- 밀도
- 1.2669 (rough estimate)
- RTECS 번호
- LZ4295770
- 굴절률
- -16.5 ° (C=2, H2O)
- 저장 조건
- 2-8°C
- 용해도
- H2O: 0.1 g/mL, 투명, 무색
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
- 색상
- 흰색에서 거의 흰색
- 수소이온지수(pH)
- 11 (10g/l, H2O, 20℃)
- optical activity
- [α]20/D 16.5±0.5°, c = 2% in H2O
- 수용성
- 100g/100mL(25℃)
- 감도
- Air Sensitive & Hygroscopic
- Merck
- 14,6078
- BRN
- 385906
- InChIKey
- MBBZMMPHUWSWHV-VZFHVOOUSA-N
- LogP
- -3.370 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 | 36/37/38 | ||
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안전지침서 | 24/25 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 3-10-23 | ||
자연 발화 온도 | ~662 °F | ||
TSCA | Yes | ||
HS 번호 | 29221980 | ||
독성 | LD50 orally in Rabbit: > 5000 mg/kg | ||
기존화학 물질 | KE-09604 |
메틸글루카민 C화학적 특성, 용도, 생산
화학적 성질
Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.용도
N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.생산 방법
Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.정의
ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.일반 설명
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.
Pharmaceutical Applications
Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.Safety
Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.LD50 (mouse, IP): 1.68 g/kg
저장
Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
Purification Methods
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]비 호환성
Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.Regulatory Status
Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.메틸글루카민 준비 용품 및 원자재
원자재
준비 용품
메틸글루카민 공급 업체
글로벌( 693)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Wuhan Silworld Chemical Co.,Ltd | +86-027-85613400 +86-15827173649 |
info@silworldchemical.com | China | 178 | 58 |
Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 |
hbjbtech@163.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 |
wrjmoon2000@163.com | China | 354 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 |
admin@hbsaisier.cn | China | 690 | 58 |
메틸글루카민 관련 검색:
인드메타신
meglumine-gadolinium-edt
FLUNIXIN MEGLUMINE SALT,FLUNIXINE MEGLUMINE SALT,FLUNIXIN MEGLUMINE
N-METHYL GLUCAMINE ANTIMONIATE / MEGLUMINE ANTIMONIATE
Diatrizoate meglumine (USP),MEGLUMINE DIATRIZOATE,DIATRIZOATE MEGLUMINE,diatrizoic acid meglumine salt
Flunixin meglumine
D-GLUCAMINE
Glucosamine
gadolinium DOTA meglumine
iodipamide meglumine salt,meglumine iodipamide
MEGLUMINE - REFERENCE SPECTRUM
Iothalamate meglumine
meglumine ioxithalamate,ioxitalamic acid meglumine salt
meglumine iodamide,iodamide meglumine salt
meglumine indomethacinate
MEGLUMINE DIATRIAZOATE
iodoxamic acid meglumine salt
FLUNIXIN MEGLUMINE IMP. C (EP): ETHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE