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메틸글루카민

메틸글루카민
메틸글루카민 구조식 이미지
카스 번호:
6284-40-8
한글명:
메틸글루카민
동의어(한글):
메틸글루카민
상품명:
Meglumine
동의어(영문):
N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
CBNumber:
CB6411710
분자식:
C7H17NO5
포뮬러 무게:
195.21
MOL 파일:
6284-40-8.mol

메틸글루카민 속성

녹는점
129-131.5 °C (lit.)
끓는 점
331.88°C (rough estimate)
알파
-16.5 º (c=10, H2O, on dry sub)
밀도
1.2669 (rough estimate)
굴절률
-16.5 ° (C=2, H2O)
RTECS 번호
LZ4295770
저장 조건
2-8°C
용해도
H2O: 0.1 g/mL, clear, colorless
물리적 상태
Crystalline Powder
산도 계수 (pKa)
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
색상
White to almost white
수소이온지수(pH)
11 (10g/l, H2O, 20℃)
optical activity
[α]20/D 16.5±0.5°, c = 2% in H2O
수용성
100 g/100 mL (25 ºC)
감도
Air Sensitive & Hygroscopic
Merck
14,6078
BRN
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
NIST
N-methylglucamine(6284-40-8)
EPA
Meglumine (6284-40-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 36/37/38
안전지침서 24/25
WGK 독일 3
F 고인화성물질 3-10-23
자연 발화 온도 ~662 °F
TSCA Yes
HS 번호 29221980
독성 LD50 orally in Rabbit: > 5000 mg/kg
기존화학 물질 KE-09604
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
NFPA 704
0
0 1

메틸글루카민 MSDS


Meglumine

메틸글루카민 C화학적 특성, 용도, 생산

화학적 성질

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

용도

N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

생산 방법

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

정의

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

저장

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

비 호환성

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

메틸글루카민 준비 용품 및 원자재

원자재

준비 용품


메틸글루카민 공급 업체

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