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SJA6017

SJA6017 구조식 이미지

카스 번호:: 190274-53-4

상품명:: SJA6017

동의어(영문):: SJA6017;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde;Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-

CBNumber:: CB6427018

분자식:: C17H25FN2O4S

포뮬러 무게:: 372.45

MOL 파일:: 190274-53-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 41

SJA6017 속성

밀도: 1.185±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO: 5 mg/ml

물리적 상태: A lyophilized solid

산도 계수 (pKa): 9.04±0.50(Predicted)

안전

SJA6017 C화학적 특성, 용도, 생산

개요

Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC₅₀ = 7.5 nM) and m-calpain (calpain-2; IC₅₀ = 78 nM). It also inhibits cathepsins B and L (IC₅₀s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

SJA6017 준비 용품 및 원자재

원자재

준비 용품

SJA6017 공급 업체

글로벌( 41)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Alabiochem Tech.Co., Ltd.	0512-58900862 400-0707518	sales@alabiochem.com	China	995	59
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696;	info@hanhongsci.com	China	42982	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60

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SJA6017