옥사제팜
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옥사제팜 속성
- 녹는점
- 205-206°
- 끓는 점
- 506.5±50.0 °C(Predicted)
- 밀도
- 1.3052 (rough estimate)
- 굴절률
- 1.5200 (estimate)
- 인화점
- 11 °C
- 저장 조건
- −20°C
- 용해도
- 물에는 거의 녹지 않으며, 에탄올에는 약간 녹습니다(96%).
- 산도 계수 (pKa)
- pKa 1.6/11.6(5% MeOH in H2O,t =20,I=0.15) (Uncertain)
- 수용성
- 20mg/L(22℃)
- CAS 데이터베이스
- 604-75-1(CAS DataBase Reference)
- IARC
- 2B (Vol. Sup 7, 66) 1996
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 40-39/23/24/25-23/24/25-11 | ||
안전지침서 | 7-16-36/37-45 | ||
유엔번호(UN No.) | UN 1230 3/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DF1400000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 2933910000 | ||
유해 물질 데이터 | 604-75-1(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats (mg/kg): >5010, >5010 orally (Goldenthal) |
옥사제팜 C화학적 특성, 용도, 생산
화학적 성질
Off-White Solid용도
Anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).정의
ChEBI: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.일반 설명
Oxazepam, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazpin-2-one (Serax), isan active metabolite of both chlordiazepoxide and diazepamand can be considered a prototype for the 3-hydroxy benzo-diazepines. It is much more polar than diazepam. Oxazepam is rapidlyinactivated to glucuronidated metabolites that are excretedin the urine. Thus, the half-life of oxazepam is about 4 to 8hours, and it is marketed as a short-acting anxiolytic. As aresult, its cumulative effects with chronic therapy are muchless than with long-acting benzodiazepine such as chlordiazepoxideand diazepam.공기와 물의 반응
Insoluble in water.반응 프로필
OXAZEPAM is stable in light and is non hygroscopic. OXAZEPAM is stable in neutral solution. OXAZEPAM is hydrolyzed by acids and bases.화재위험
Flash point data for OXAZEPAM are not available; however, OXAZEPAM is probably combustible.Pharmacokinetics
The half-life of oxazepam is approximately 4 to 8 hours, and cumulative effects with chronic therapy are much less than with long-acting benzodiazepines, such as chlordiazepoxide and diazepam. Lorazepam is the 2′-chloro derivative of oxazepam and has a similarly short half-life (2–6 hours) and pharmacological activity.신진 대사
Oxazepam is an active metabolite of both chlordiazepoxide and diazepam and is marketed separately, as a shortacting anxiolytic agent. Oxazepam is rapidly inactivated to glucuronidated metabolites that are excreted in the urine.옥사제팜 준비 용품 및 원자재
원자재
준비 용품
옥사제팜 공급 업체
글로벌( 0)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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옥사제팜 관련 검색:
옥사제팜 로라제팜 테마제팜
LORMETAZEPAM
Pivoxazepam
7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Doxefazepam
3-(Acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Cinolazepam
camazepam
OXAZEPAM (1MG/ML METHANOLSOLN)
perhexiline
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
LORAZEPAM-D4
(R)-Lorazepam
(S)-Lorazepam
temazepam glucuronide
TEMAZEPAM-D5