PHALLOIDIN

PHALLOIDIN 구조식 이미지
카스 번호:
17466-45-4
상품명:
PHALLOIDIN
동의어(영문):
Nsc523214;PHALLOIDIN;phalloidine;Glycerol Formal Impurity 5;Phalloidin *CAS#: 17466-45-4*;PHALLOIDIN, AMANITA PHALLOIDES;Phalloidin trifluoroacetate salt;PHALLOIDIN FROM AMANITA PHALLOIDES;Phalloidin, 90%, from Amanita phalloides;pto-l-tryptophyl-4,5-dihydroxy-l-leucyl),cyclic(3,6)-sulfide
CBNumber:
CB6458766
분자식:
C35H48N8O11S
포뮬러 무게:
788.87
MOL 파일:
17466-45-4.mol
MSDS 파일:
SDS

PHALLOIDIN 속성

녹는점
280-282°
알파
+55.7°(D/20℃)(c=0.5,メタノール)
밀도
1.1612 (rough estimate)
굴절률
1.7400 (estimate)
저장 조건
+2C to +8C
용해도
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Water: 0.5 mg/ml (warm)
물리적 상태
백색 결정성 고체
끓는 점
1370.5±65.0 °C(Predicted)
산도 계수 (pKa)
13.03±0.70(Predicted)
색상
물에서 나온 육수화물, 바늘 또는 결정
수용성
Soluble to 1 mg/ml in water
Merck
13,7273
BRN
4347460
안정성
안정적인. 강한 산화제와 호환되지 않습니다.
안전
  • 위험 및 안전 성명
위험품 표기 T+
위험 카페고리 넘버 26/27/28
안전지침서 22-28-36/37-45
유엔번호(UN No.) UN 3462 6.1/PG 2
WGK 독일 3
RTECS 번호 SE9800000
F 고인화성물질 18
위험 등급 6.1(a)
포장분류 I
HS 번호 2934999090
유해 물질 데이터 17466-45-4(Hazardous Substances Data)
독성 LD50 i.m. in albino mice: 3.3 mg/g (Vogt); LD50 i.p. in mice: 2 mg/kg (Wieland, Wieland)
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P262 눈, 피부, 의복에 묻지 않도록 하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
NFPA 704
0
4 0

PHALLOIDIN C화학적 특성, 용도, 생산

개요

Phalloidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds F-actin and stabilizes actin fibers. Fluorescently labeled phalloidin is commonly used to stain F-actin in cells.

화학적 성질

white powder

용도

Phalloidin has been used:

정의

ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.

일반 설명

Phalloidin is a phallotoxin produced by death cap mushroom Amanita phalloides. It is a cyclic peptide, which interacts with actin, and this was first identified in phalloidin-poisoned rats. It is a heptapeptide, cyclic in nature, with a crosslink between tryptophan at position 6 and cysteine at position 3. The side chain of amino acid 7 (γ-δ-dihydroxyleucine) in phalloidin, is accessible to modifications, through which fluorescently labeled phalloidin compounds can be produced.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. Whenheated to decomposition it emits toxic fumes of SOx, and NOx.

효소 저해제

This bicyclic heptapeptide toxin (FW = 788.88 g/mol; CAS 17466-45-4) is was first isolated from the poisonous green fungus Amanita phalloides. Primary Mode of Action: Phalloidin binds preferentially to filamentous actin; little or no binding to globular actin has been detected. such preferential action stimulates actin polymerization, and phalloidin lowers the actin monomer critical concentration by 30x, from 50-100 nM down to 2-3 nM. When present at 1 to 10 concentration ratio of phalloidin to total actin subunits, actin filaments are also greatly stabilized toward depolymerization. Effects on Actin Filaments: Cellular processes requiring filament disassembly are likewise inhibited. Depolymerization of F-actin by cytochalasins, potassium iodide, and elevated temperatures are inhibited by phalloidin binding. Because the toxin and its fluorescent derivatives are relatively small, a wide variety of actin-binding proteins can still bind to phalloidin-labeled filamentts. Perhaps more significantly, phalloidin-labeled actin filaments retain many of their functional properties, such that phalloidin-labeled, glycerinated muscle fibers can still contract, and labeled actin filaments still move on myosin that has been tethered to solid-phase substrates. Phalloidin can be also be used to assess the relativeconcentrations of these two forms of actin as well as a means to label actin filaments in a cell (See Phallacidin).

PHALLOIDIN 준비 용품 및 원자재

원자재

준비 용품


PHALLOIDIN 공급 업체

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Hubei Aiputi Bioengineering Co., Ltd. 17762444226
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
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Beijing Ouhe Technology Co., Ltd 010-82967028 13552068683
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Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
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Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 18521732826;
market@aladdin-e.com China 24835 65

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