PHALLOIDIN
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PHALLOIDIN 속성
- 녹는점
- 280-282°
- 알파
- +55.7°(D/20℃)(c=0.5,メタノール)
- 밀도
- 1.1612 (rough estimate)
- 굴절률
- 1.7400 (estimate)
- 저장 조건
- +2C to +8C
- 용해도
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Water: 0.5 mg/ml (warm)
- 물리적 상태
- 백색 결정성 고체
- 끓는 점
- 1370.5±65.0 °C(Predicted)
- 산도 계수 (pKa)
- 13.03±0.70(Predicted)
- 색상
- 물에서 나온 육수화물, 바늘 또는 결정
- 수용성
- Soluble to 1 mg/ml in water
- Merck
- 13,7273
- BRN
- 4347460
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
안전
- 위험 및 안전 성명
위험품 표기 | T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 26/27/28 | ||
안전지침서 | 22-28-36/37-45 | ||
유엔번호(UN No.) | UN 3462 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | SE9800000 | ||
F 고인화성물질 | 18 | ||
위험 등급 | 6.1(a) | ||
포장분류 | I | ||
HS 번호 | 2934999090 | ||
유해 물질 데이터 | 17466-45-4(Hazardous Substances Data) | ||
독성 | LD50 i.m. in albino mice: 3.3 mg/g (Vogt); LD50 i.p. in mice: 2 mg/kg (Wieland, Wieland) |
PHALLOIDIN C화학적 특성, 용도, 생산
개요
Phalloidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds F-actin and stabilizes actin fibers. Fluorescently labeled phalloidin is commonly used to stain F-actin in cells.화학적 성질
white powder용도
Phalloidin has been used:- As a supplement in PEM buffer and dimethyl sulfoxide (DMSO).
- As a drug.
- In immunohistochemistry to stain F-actin.
정의
ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.일반 설명
Phalloidin is a phallotoxin produced by death cap mushroom Amanita phalloides. It is a cyclic peptide, which interacts with actin, and this was first identified in phalloidin-poisoned rats. It is a heptapeptide, cyclic in nature, with a crosslink between tryptophan at position 6 and cysteine at position 3. The side chain of amino acid 7 (γ-δ-dihydroxyleucine) in phalloidin, is accessible to modifications, through which fluorescently labeled phalloidin compounds can be produced.Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. Whenheated to decomposition it emits toxic fumes of SOx, and NOx.효소 저해제
This bicyclic heptapeptide toxin (FW = 788.88 g/mol; CAS 17466-45-4) is was first isolated from the poisonous green fungus Amanita phalloides. Primary Mode of Action: Phalloidin binds preferentially to filamentous actin; little or no binding to globular actin has been detected. such preferential action stimulates actin polymerization, and phalloidin lowers the actin monomer critical concentration by 30x, from 50-100 nM down to 2-3 nM. When present at 1 to 10 concentration ratio of phalloidin to total actin subunits, actin filaments are also greatly stabilized toward depolymerization. Effects on Actin Filaments: Cellular processes requiring filament disassembly are likewise inhibited. Depolymerization of F-actin by cytochalasins, potassium iodide, and elevated temperatures are inhibited by phalloidin binding. Because the toxin and its fluorescent derivatives are relatively small, a wide variety of actin-binding proteins can still bind to phalloidin-labeled filamentts. Perhaps more significantly, phalloidin-labeled actin filaments retain many of their functional properties, such that phalloidin-labeled, glycerinated muscle fibers can still contract, and labeled actin filaments still move on myosin that has been tethered to solid-phase substrates. Phalloidin can be also be used to assess the relativeconcentrations of these two forms of actin as well as a means to label actin filaments in a cell (See Phallacidin).PHALLOIDIN 준비 용품 및 원자재
원자재
준비 용품
PHALLOIDIN 공급 업체
글로벌( 107)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Nanjing TGpeptide | +86-13347807150 +86-13347807150 |
support@tgpeptide.com | China | 3279 | 58 |
Zhejiang Hangyu API Co., Ltd | +8617531972939 |
anna@api-made.com | China | 2938 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
Hubei Aiputi Bioengineering Co., Ltd. | 17762444226 |
d17762444226@163.com | China | 2402 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
Beijing Ouhe Technology Co., Ltd | 010-82967028 13552068683 |
2355560935@qq.com | China | 12426 | 60 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 |
sales@meilune.com | China | 4647 | 58 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; |
market@aladdin-e.com | China | 24835 | 65 |
PHALLOIDIN 관련 검색:
PHALLOIDIN
PHALLOIDIN, BIOTIN LABELED
PHALLOIDIN-FITC LABELED,FITC - PHALLOIDIN CONJUGATE,PHALLOIDIN (FITC),PHALLOIDIN - FLUORESCEIN ISOTHIOCYANATE CONJUGATE
(3S)-1-(2-AMINOETHYL)-3-PYRROLIDINOL
PHALLOIDIN, RHODAMINE X CONJUGATED,RHODAMINE PHALLOIDIN
TETRAMETHYLRHODAMINE B ISOTHIOCYANATE PHALLOIDIN CONJUGATE,PHALLOIDIN-TRITC LABELED,PHALLOIDIN-TETRAMETHYLRHODAMINE B ISOTHIOCYANATE CONJUGATE,PHALLOIDIN-TRITC
FLUORESCEIN PHALLOIDIN
4-(3-(biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)-2-methyl-1,3-dithiolane-2-yl-(Ala(7))phalloidin
PHALLOIDIN FITC LABELED (MIXED ISOMERS)
PHALLOIDIN TRITC LABELED MIXED ISOMERS
Ala(7)-phalloidin
PHALLOIDIN OLEATE
BODIPY(R) 581/591 PHALLOIDIN
BIOTIN-XX PHALLOIDIN
ALEXA FLUOR(R) 594 PHALLOIDIN
rhodamine B isothiocyanate phalloidin
ALEXA FLUOR(R) 633 PHALLOIDIN
ALEXA FLUOR(R) 488 PHALLOIDIN