Pimobendan
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Pimobendan 속성
- 녹는점
- approximate 243℃ (dec.)
- 밀도
- 1.36
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 용해성5mg/mL, 투명(가온)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 10.55±0.10(Predicted)
- 색상
- 흰색에서 베이지색
- InChI
- InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
- InChIKey
- GLBJJMFZWDBELO-UHFFFAOYSA-N
- SMILES
- C1(=O)NN=C(C2C=C3NC(C4=CC=C(OC)C=C4)=NC3=CC=2)C(C)C1
- CAS 데이터베이스
- 74150-27-9(CAS DataBase Reference)
Pimobendan C화학적 특성, 용도, 생산
개요
Pimobendan, a novel cardiotonic vasodilator, was introduced in Japan for the treatment of acute and mild to moderate chronic heart failure. It is a phosphodiesterase Ⅲ inhibitor and is able to enhance sensitization of myocardial contractile regulatory protein to calcium ions. The combination of these effects contribute to its inotropic activity. In patients with severe congestive heart failure, orally administered pimobendan improves cardiac index, stroke volume index, pulmonary wedge pressure, and systemic and pulmonary vascular resistance. Pimobendan is reported to be well tolerated and largely devoid of the proarrhythmic effects of classical phosphodiesterase Ill inhibitors. Studies also suggested that combination of the inotropic agent pimobendan with an ACE inhibitor such as enalapril may be superior to monotherapy for heart failure patients.화학적 성질
White Solid용도
Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.정의
ChEBI: Pimobendan is a pyridazinone and a member of benzimidazoles. It has a role as a cardiotonic drug, a vasodilator agent and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.생물학적 활성
Pimobendan is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 0.32 μM for guinea pig cardiac enzyme) that is selective for PDE3 over PDE1, PDE2, and PDE4 (IC50s = >30 μM). It is also a calcium sensitizer, decreasing the concentration of calcium required for half-maximal contractile force in isolated, skinned porcine ventricular fibers. Pimobendan increases the force of contraction in electrically-stimulated isolated guinea pig papillary muscles with an EC50 value of 6 μM, indicating positive inotropic effects. It increases survival time in dogs with congestive heart failure due to myxomatous mitral valve disease when administered in combination with angiotensin-converting enzyme inhibitors and furosemide . Formulations containing pimobendan have been used in the treatment of heart failure in dogs.Mechanism of action
The mechanism of mild mitral regurgitation (MR) in dogs treated with Pimobendan is a dual mechanism of action, which enhances myocardial contractility by increasing calcium sensitisation of troponin C and promotes vasodilatation by inhibiting PDEIII.부작용
The most common side effects include gastrointestinal effects such as decreased appetite, and diarrhea. Other possible side effects include lethargy and difficulty breathing This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.Pimobendan 준비 용품 및 원자재
원자재
준비 용품
Pimobendan 공급 업체
글로벌( 307)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 |
trade.kilopharma@foxmail.com | China | 27 | 58 |
Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 |
info@hanpets.com | China | 26 | 58 |
Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 |
sales@pipharma.com.cn | China | 148 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7845 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Pimobendan 관련 검색:
3(2H)-피리다진원
Sildenafil
Famciclovir
Pimecrolimus
I-BET151 (GSK1210151A)
Selumetinib
PF-562271
Quizartinib (AC220)
GSK256066
SGX-523
5-Methyl-3(2H)-pyridazinone
Pimobendan
4,5-DIHYDRO-6-METHYL-3(2H)-PYRIDAZINONE HYDRATE, 98
l-Pimobendan
PIMOBENDAN FOR SYSTEM SUITABILITY
2-(4-METHOXYPHENYL)-5-METHYL-1H-BENZO[D]IMIDAZOLE
d-Pimobendan