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티오글리콜산

티오글리콜산
티오글리콜산 구조식 이미지
카스 번호:
68-11-1
한글명:
티오글리콜산
동의어(한글):
티오글리콜산;메르캅토초산;머캅토초산;티오글리코릭산;치오글라이콜릭애씨드;티오글라이콜릭애씨드;멜캅토아세트산;알파-멜캅토아세트산;술프히드릴아세트산;2-티오글리콜산
상품명:
Mercaptoacetic acid
동의어(영문):
TGA;usafcb-35;MEQUINDOX;USAF cb-35;thioglycolic;thiovanicacid;Thioglycolate;Thiovanic acid;Thiovanie acid;mercaptoacetic
CBNumber:
CB6477604
분자식:
C2H4O2S
포뮬러 무게:
92.12
MOL 파일:
68-11-1.mol

티오글리콜산 속성

녹는점
−16 °C(lit.)
끓는 점
96 °C5 mm Hg(lit.)
밀도
1.326 g/mL at 20 °C(lit.)
증기 밀도
3.2 (vs air)
증기압
0.4 mm Hg ( 25 °C)
굴절률
n20/D 1.505(lit.)
인화점
126 °C
저장 조건
2-8°C
물리적 상태
Liquid
산도 계수 (pKa)
3.68(at 25℃)
색상
clear clear, colorless
수소이온지수(pH)
1 (H2O, 20℃)
수용성
soluble
감도
Air Sensitive
Merck
14,9336
BRN
506166
노출 한도
TLV-TWA 1 ppm (~3.8 mg/m3) (ACGIH).
CAS 데이터베이스
68-11-1(CAS DataBase Reference)
NIST
Acetic acid, mercapto-(68-11-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,T+
위험 카페고리 넘버 23/24/25-34-26-24/25
안전지침서 25-27-28-45-36/37-28C-23
유엔번호(UN No.) UN 1940 8/PG 2
WGK 독일 1
RTECS 번호 AI5950000
F 고인화성물질 9-13-23
자연 발화 온도 662 °F
TSCA Yes
위험 등급 8
포장분류 II
HS 번호 29309070
유해 물질 데이터 68-11-1(Hazardous Substances Data)
독성 LD50 orally in rats: 0.15 ml/kg (Deichmann, Mergard)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H290 금속을 부식시킬 수 있음 금속 부식성물질 구분 1 경고 P234, P390, P404
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H311 피부와 접촉하면 유독함 급성 독성 물질 - 경피 구분 3 위험 P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H330 흡입하면 치명적임 급성 독성 물질 흡입 구분 1, 2 위험 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H331 흡입하면 유독함 급성 독성 물질 흡입 구분 3 위험 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H402 수생생물에 유해함 수생 환경유해성 물질 - 급성 구분 3
예방조치문구:
P234 원래의 용기에만 보관하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P272 작업장 밖으로 오염된 의복을 반출하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P284 호흡 보호구를 착용하시오.
P390 물질손상을 방지하기 위해 누출물을 흡수시키시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P307+P311 노출된 경우,독성 물질 센터 또는 의사에게 전화하기
P405 밀봉하여 저장하시오.
P406 부식을 방지하여 보관하시오/...내부식성 용기
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

티오글리콜산 MSDS


Mercaptoacetic acid

티오글리콜산 C화학적 특성, 용도, 생산

용도

1) 수용액은 모발의 콜드 웨이브용 약품. 2) 분석용 시약. i) 암모니아 알칼리성에서 철(Ⅱ, Ⅲ) 이온과 반응하며, 가용성의 적자색 발색 화합물을 만들기 때문에 철의 비색 분석에 또는 철의 마스킹제로 이용된다. 코발트, 니켈, 납, 비스무트, 수은(Ⅰ), 우라늄(Ⅵ), 은, 금과도 발색 화합물을 만든다. ii) 미량의 구리(Ⅱ) 이온이 티오글리콜산의 산화 반응 촉매가 된다. 이것이 구리의 정량에 이용된다. iii) 몰리브덴을 티오시안산 착물로서 비색 분석할 때 환원제로 사용된다.

개요

Thio glycolic acid (TGA) is the organic compound HSCH2CO2H . It contains both a thiol (mercaptan) and a carboxylic acid. It is a clear liquid with a strong unpleasant odor. It is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
TGA was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. TGA is the precursor to ammonium thioglycolate that is used for permanents. TGA and its derivatives break the disulfide bonds in the cortex of hair. One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
TGA is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
TGA, usually as its dianion, forms complexes with metal ions. Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.

화학적 성질

Thioglycolic acid is a colorless liquid with a strong unpleasant odor like rotten eggs.

화학적 성질

Also known as mercaptoacetic acid, HSCH2COOH is a colorless liquid with a strong unpleasant odor. Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.

용도

Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.

용도

Sensitive reagent for iron, molybdenum, silver, tin. With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and thioglycolic acid, a yellow precipitate forms. Used in the manufacture of thioglycolates. The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory. The sodium salt also is used in bacteriology in the preparation of thioglycolate media.

용도

Mercaptoacetic acid is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.

일반 설명

A colorless liquid with an unpleasant odor. Density 1.325 g / cm3. Used to make permanent wave solutions and depilatories. Corrosive to metals and tissue.

공기와 물의 반응

Readily oxidized by air. Water soluble.

반응 프로필

Mercaptoacetic acid is readily oxidized by air . Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases. Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials may generate heat and toxic and flammable gases. May react with acids to liberate hydrogen sulfide. Neutralizes bases in exothermic reactions. Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat. Reacts with carbonates and bicarbonates.

위험도

Toxic by ingestion and inhalation, strong irritant to tissue, eyes, and skin.

건강위험

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

건강위험

Mercaptoacetic acid is a highly toxic and ablistering compound. Even a 10% solutionwas lethal to most experimental animals by dermal absorption. The oral LD50 value ofundiluted acid is less than 50 mg/kg (Patty1963). The lethal dose in rabbits by skinabsorption is 300 mg/kg. The acute toxicsymptoms in test animals include weakness,respiratory distress, convulsions, irritation ofthe gastrointestinal tract, and liver damage.
Mercaptoacetic acid is a severe irritant.Contact with eyes can cause conjunctivalinflammation and corneal opacity. Skin contact can result in burns and necrosis.

화재위험

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. A corrosive irritant to skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of SOx. See also MERCAPTANS and HYDROGEN SULFIDE.

잠재적 노출

Thioglycolic acid is used to make thioglycolates; in sensitivity tests for iron; in formulations of permanent wave solutions and depilatories; in pharmaceutical manufacture; as a stabilizer in vinyl plastics.

운송 방법

UN1940 Thyoglycolic acid, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Mix the acid with an equal volume of *benzene; the *benzene is then distilled off to dehydrate the acid. After heating to 100o to remove most of the *benzene, the residue is distilled under vacuum and stored in sealed ampoules at 3o. [Eshelman et al. Anal Chem 22 844 1960, Beilstein 3 IV 1130.]

비 호환성

Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Air, strong oxidizers; bases, active metals, for example, sodium potassium, magnesium, and calcium. Readily oxidized by air. Thermal decomposition causes release of hydrogen sulfide. May attack various metals.

폐기물 처리

Dissolve in flammable solvent and burn in furnace equipped with afterburner and alkaline scrubber.

티오글리콜산 준비 용품 및 원자재

원자재

준비 용품


티오글리콜산 공급 업체

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