SENECIONINE
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SENECIONINE 속성
- 녹는점
- 236 °C(lit.)
- 알파
- D25 -55.1° (c = 0.034 in chloroform)
- 끓는 점
- 472.03°C (rough estimate)
- 밀도
- 1.266 g/cm3
- 굴절률
- 1.5100 (estimate)
- 저장 조건
- −20°C
- 용해도
- DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml
- 산도 계수 (pKa)
- 12.81±0.40(Predicted)
- optical activity
- [α]25/D 55.1°, c = 0.034% in chloroform
- BRN
- 8162955
- InChIKey
- HKODIGSRFALUTA-JTLQZVBZSA-N
- LogP
- 0.880 (est)
안전
- 위험 및 안전 성명
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25 | ||
| 안전지침서 | 45 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | VT5710000 | ||
| F 고인화성물질 | 10-23 | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | II | ||
| 유해 물질 데이터 | 130-01-8(Hazardous Substances Data) | ||
| 독성 | LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris) |
SENECIONINE C화학적 특성, 용도, 생산
개요
Senecionine is a pyrrolizidine alkaloid that has been found in S. vulgaris and has hepatotoxic properties. It is metabolized by the cytochrome P450 (CYP) isoform CYP3A in the liver to the detoxification product senecionine N-oxide and reactive metabolites including dehydropyrrolizidine alkaloids and dehydrotetronecine. Senecionine (20 μM) induces mitochondrial depolarization and fragmentation in primary cultured mouse hepatocytes and increases apoptosis in a concentration-dependent manner. In rats, senecionine (35 mg/kg, p.o.) induces liver injury, increases serum levels of bilirubin and various bile acids, including taurocholic acid, glycocholic acid, and deoxycholic acid, and increases the activity of alanine aminotransferase and aspartate aminotransferase in serum. Senecionine-induced hepatotoxicity is associated with lipid peroxidation and glutathione depletion.정의
ChEBI: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.Safety Profile
Poison by intravenous,intraperitoneal, and possibly other routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.참고 문헌
Grandval, Lajoux., Cornpt. rend., 120,1120 (1895)Grandval, Lajoux., Bull. Soc. Chirn. Fr., 13,942 (1895)
Manske., Can. J. Res., S, 651 (1931)
Manske., ibid, 14B, 6 (1936)
Barger, Blackie., J. Chern. Soc., 584 (1937)
Blackie., Pharrn. J., 138,102 (1937)
Manske., Can. J. Res., 17B, I (1939)
SENECIONINE 준비 용품 및 원자재
원자재
준비 용품
SENECIONINE 공급 업체
글로벌( 111)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 |
jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
SENECIONINE 관련 검색:
메타크릴산 디에틸아미노에틸 디아미노에틸아크릴레이트
SENECIONINE(RG)
(+)-3-METHYLHEXANEDIOIC ACID
3-METHOXYPYRROLIDINE
senecionine N-oxide
(R)-3-METHOXYPYRROLIDINE
SENECIONINE
3-Methyladipic acid
(R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE
3-ETHOXYPYRROLIDINE
retronecine
3-(DIMETHYLAMINO)PROPYL ACRYLATE
anacrotine
3-BUTOXYPYRROLIDINE
3-PROPOXYPYRROLIDINE
ETHYL 5-METHYL-5-HEXENOATE
(S)-ALLYL LACTATE